Spinal Cord Diffusion Tensor Imaging In Patients With Sensory Neuronopathy

dc.creatorCasseb
dc.creatorRaphael Fernandes; de Paiva
dc.creatorJean Levi Ribeiro; Branco
dc.creatorLucas Melo Teixeira; Martinez
dc.creatorAlberto Rolim Muro; Reis
dc.creatorFabiano; de Lima-Junior
dc.creatorJose Carlos; Castellano
dc.creatorGabriela; Franca Junior
dc.creatorMarcondes Cavalcante
dc.date2016
dc.datenov
dc.date2017-11-13T11:33:36Z
dc.date2017-11-13T11:33:36Z
dc.date.accessioned2018-03-29T05:48:01Z
dc.date.available2018-03-29T05:48:01Z
dc.identifierNeuroradiology. Springer, v. 58, p. 1103 - 1108, 2016.
dc.identifier0028-3940
dc.identifier1432-1920
dc.identifierWOS:000388690700006
dc.identifier10.1007/s00234-016-1738-2
dc.identifierhttps://link-springer-com.ez88.periodicos.capes.gov.br/article/10.1007/s00234-016-1738-2
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/326299
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1363305
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionWe investigated whether MR diffusion tensor imaging (DTI) analysis of the cervical spinal cord could aid the (differential) diagnosis of sensory neuronopathies, an underdiagnosed group of diseases of the peripheral nervous system. We obtained spinal cord DTI and T2WI at 3 T from 28 patients, 14 diabetic subjects with sensory-motor distal polyneuropathy, and 20 healthy controls. We quantified DTI-based parameters and looked at the hyperintense T2W signal at the spinal cord posterior columns. Fractional anisotropy and mean diffusivity values at C2-C3 and C3-C4 levels were compared between groups. We also compared average fractional anisotropy (mean of values at C2-C3 and C3-C4 levels). A receiver operating characteristic (ROC) curve was used to determine diagnostic accuracy of average fractional anisotropy, and we compared its sensitivity against the hyperintense signal in segregating patients from the other subjects. Mean age and disease duration were 52 +/- 10 and 11.4 +/- 9.3 years in the patient group. Eighteen subjects had idiopathic disease and 6 dysimmune etiology. Fractional anisotropy at C3-C4 level and average fractional anisotropy were significantly different between patients and healthy controls (p < 0.001 and < 0.001) and between patients and diabetic subjects (p = 0.019 and 0.027). Average fractional anisotropy presented an area under the curve of 0.838. Moreover, it had higher sensitivity than visual detection of the hyperintense signal (0.86 vs. 0.54), particularly for patients with short disease duration. DTI-based analysis enables in vivo detection of posterior column damage in sensory neuronopathy patients and is a useful diagnostic test for this condition. It also helps the differential diagnosis between sensory neuronopathy and distal polyneuropathies.
dc.description58
dc.description11
dc.description1103
dc.description1108
dc.descriptionFAPESP (Sao Paulo Research Foundation - Brazilian governmental agency) [2013/01766-7, 2013/07559-3]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherSpringer
dc.publisherNew York
dc.relationNeuroradiology
dc.rightsfechado
dc.sourceWOS
dc.subjectDiffusion Tensor Imaging (dti)
dc.subjectSensory Neuronopathy
dc.subjectMri
dc.subjectSpinal Cord
dc.subjectPeripheral Neuronopathy
dc.titleSpinal Cord Diffusion Tensor Imaging In Patients With Sensory Neuronopathy
dc.typeArtículos de revistas


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