Knocking Down Amygdalar Ptp1b In Diet-induced Obese Rats Improves Insulin Signaling/action, Decreases Adiposity And May Alter Anxiety Behavior

dc.creatorMendes
dc.creatorNatalia Ferreira; Castro
dc.creatorGisele; Guadagnini
dc.creatorDioze; Tobar
dc.creatorNatalia; Cognuck
dc.creatorSusana Quiros; Kagohara Elias
dc.creatorLucila Leico; Boer
dc.creatorPatricia Aline; Prada
dc.creatorPatricia Oliveira
dc.date2017
dc.datemaio
dc.date2017-11-13T11:33:29Z
dc.date2017-11-13T11:33:29Z
dc.date.accessioned2018-03-29T05:47:57Z
dc.date.available2018-03-29T05:47:57Z
dc.identifierMetabolism-clinical And Experimental. W B Saunders Co-elsevier Inc, v. 70, p. 1 - 11, 2017.
dc.identifier0026-0495
dc.identifier1532-8600
dc.identifierWOS:000400037600001
dc.identifier10.1016/j.metabol.2017.01.029
dc.identifierhttp://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S0026049517300422
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/326280
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1363286
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionProtein tyrosine phosphatase 1B (PTP1B) has been extensively implicated in the regulation of body weight, food intake, and energy. expenditure. The role of PTP1B appears to be cell and brain region dependent. Results. Herein, we demonstrated that chronic high-fat feeding enhanced PTP1B expression in the central nucleus of the amygdala (CeA) of rats compared to rats on chow: Knocking down PTP1B with oligonucleotide antisense (ASO) decreased its expression and was sufficient to improve the anorexigenic effect of insulin through IR/Akt signaling in the CeA. ASO treatment reduces body weight, fat mass, serum leptin levels, and food intake and also increases energy expenditure, without altering ambulatory activity. These changes were explained, at least in part, by the improvement of insulin sensitivity in the CeA, decreasing NPY and enhancing oxytocin expression. There was a slight decline in fasting blood glucose and serum insulin levels possibly due to leanness in rats treated with ASO. Surprisingly, the elevated plus maze test revealed an anxiolytic behavior after reduction of PTP1B in the CeA. Conclusions. Thus, the present study highlights the deleterious role that the amygdalar PTP1B has on energy homeostasis in obesity states. The reduction of PTP1B in the CeA may be a strategy for the treatment of obesity, insulin resistance and anxiety disorders. (C) 2017 Elsevier Inc. All rights reserved.
dc.description70
dc.description1
dc.description11
dc.descriptionFAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo): Auxflio Regular [2015/00343-0]
dc.descriptionCEPID, Sao Paulo, Brazil [2013/07607-8]
dc.descriptionCNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) Universal [481, 084/2013-4]
dc.descriptionINCT (Instituto Nacional Ciencia e Tecnologia de Obesidade e Diabetes) [573, 856/2008-7]
dc.descriptionCAPES fellowship, Brasilia, Brazil
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageEnglish
dc.publisherW B Saunders Co-Elsevier Inc
dc.publisherPhiladelphia
dc.relationMetabolism-Clinical and Experimental
dc.rightsfechado
dc.sourceWOS
dc.subjectAmygdala
dc.subjectPtp1b
dc.subjectInsulin
dc.subjectAnxiety
dc.subjectObesity
dc.titleKnocking Down Amygdalar Ptp1b In Diet-induced Obese Rats Improves Insulin Signaling/action, Decreases Adiposity And May Alter Anxiety Behavior
dc.typeArtículos de revistas


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