Unraveling The Role Of High-intensity Resistance Training On Left Ventricle Proteome: Is There A Shift Towards Maladaptation?

dc.creatorDantas
dc.creatorPatricia Sousa; Sakata
dc.creatorMaisa Mayumi; Perez
dc.creatorJuliana Dineia; Harumi Watanabe
dc.creatorRegina Lucia; Bizerra
dc.creatorFernando Cesar; das Neves
dc.creatorVander Jose; Guzzoni
dc.creatorVinicius; Marcondes
dc.creatorFernanda Klein; Casarini
dc.creatorDulce Elena; Cunha
dc.creatorTatiana Sousa
dc.date2016
dc.datemaio
dc.date2017-11-13T11:33:21Z
dc.date2017-11-13T11:33:21Z
dc.date.accessioned2018-03-29T05:47:48Z
dc.date.available2018-03-29T05:47:48Z
dc.identifierLife Sciences. Pergamon-elsevier Science Ltd , v. 152, p. 156 - 164, 2016.
dc.identifier0024-3205
dc.identifier1879-0631
dc.identifierWOS:000375728500019
dc.identifier10.1016/j.lfs.2016.03.040
dc.identifierhttp://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S0024320516301898
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/326249
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1363255
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionHigh-intensity resistance training (RT) induces adaptations that improve physiological function. However, high intensity, volume and/or frequency may lead to injury and other health issues such as adverse cardiac effects. The aim of this study was to evaluate the effect of RT on left ventricle proteome, and to identify the pathways involved on the harmful adaptations induced by this protocol. Male Wistar rats were randomized into 2 groups: Trained (T) and Sedentary (S). Animals from T group were trained for 6 weeks, and then all the animals were sacrificed and left ventricle was isolated for analysis. We identified 955 proteins, and 93 proteins were considered; 36 were expressed exclusively in T group, and 4 in S group. Based on quantitative analysis, 42 proteins were found overexpressed and 11 underexpressed in T group compared with S group. Using the Gene Ontology to relate the biological processes in which these proteins are involved, we conclude that RT protocol promotes changes similar to those found in the initial phase of heart failure, but we also observed a concomitant increased expression of protective proteins, suggesting the activation of pathways to avoid major damages on left ventricle and delay the onset of pathological hypertrophy. Statement of significance of the study: Our study shows that high-intensity RT protocol changes left ventricle proteome, modifying metabolic profile of heart tissue and inducing the expression of proteins that acts against cardiac injury. We hypothesize that these adaptations occur to prevent the onset of cardiac dysfunction. Despite highly significant, it remains to be determined whether these adaptations are sufficient to further keep left ventricle function and exert cardioprotection, and whether this panel will be shifted towards maladaptation, and heart failure. (c) 2016 Elsevier Inc. All rights reserved.
dc.description152
dc.description156
dc.description164
dc.descriptionFundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP [02/05427-8]
dc.descriptionFAEP/UNICAMP [398/03, 680/03]
dc.descriptionCAPES, Brazil
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageEnglish
dc.publisherPergamon-Elsevier Science LTD
dc.publisherOxford
dc.relationLife Sciences
dc.rightsfechado
dc.sourceWOS
dc.subjectProteomics Shotgun
dc.subjectRat Proteomics
dc.subjectHigh-intensity Resistance Training
dc.subjectCardiac Hypertrophy
dc.subjectPathological Hypertrophy
dc.titleUnraveling The Role Of High-intensity Resistance Training On Left Ventricle Proteome: Is There A Shift Towards Maladaptation?
dc.typeArtículos de revistas


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