Benefits Of Bifidobacterium Animalis Subsp Lactis Probiotic In Experimental Periodontitis

dc.creatorOliveira
dc.creatorLuiz F. F.; Salvador
dc.creatorSergio L.; Silva
dc.creatorPedro H. F.; Furlaneto
dc.creatorFlavia A. C.; Figueiredo
dc.creatorLuciene; Casarin
dc.creatorRenato; Ervolino
dc.creatorEdilson; Palioto
dc.creatorDaniela B.; Souza
dc.creatorSergio L. S.; Taba
dc.creatorMario
dc.creatorJr.; Novaes
dc.creatorArthur B.
dc.creatorJr.; Messora
dc.creatorMichel R.
dc.date2017
dc.datefev
dc.date2017-11-13T11:32:52Z
dc.date2017-11-13T11:32:52Z
dc.date.accessioned2018-03-29T05:47:25Z
dc.date.available2018-03-29T05:47:25Z
dc.identifierJournal Of Periodontology. Amer Acad Periodontology, v. 88, p. 197 - 208, 2017.
dc.identifier0022-3492
dc.identifier1943-3670
dc.identifierWOS:000394509300015
dc.identifier10.1902/jop.2016.160217
dc.identifierhttp://www-joponline-org.ez88.periodicos.capes.gov.br/doi/full/10.1902/jop.2016.160217
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/326151
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1363157
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThis study evaluates effects of topical administration of probiotic bacteria of the genus Bifidobacterium on experimental periodontitis (EP) in rats. Methods: Thirty-two rats were divided into groups C (control; without EP), EP (EP only), C-HN019 (control+probiotic), and EP-HN019 (EP+probiotic). On day 0 of the experiment, animals of groups EP and EP-HN019 received cotton ligatures around mandibular first molars (MFMs). In groups C-HN019 and EP-HN019, 1 mL of suspensions containing Bifidobacterium animalis subsp. lactis (B. lactis) HN019 was topically administered in the subgingival region of MFMs on days 0, 3, and 7. In groups C and EP, topical administrations were performed using a sham suspension (without probiotic). All animals were euthanized at day 14. Gingival tissue, hemimandibles, and oral biofilm were collected. Data were statistically analyzed (P < 0.05). Results: Group EP presented greater bone porosity, trabecular separation, and connective tissue attachment loss (CTAL) as well as reduced bone volume than all other groups (P < 0.05). In group EP-HN019, there were greater proportions of Actinomyces and Streptococcus-like species and lower proportions of Veillonella parvula, Capnocytophaga sputigena, Eikenella corrodens, and Prevotella intermedia-like species than group EP. Group EP-HN019 presented greater expressions of osteoprotegerin and beta-defensins than group EP (P < 0.05). Group EP presented greater levels of interleukin-1 beta and receptor activator of nuclear factor-kappa B ligand than group EP-HN019 (P < 0.05). Conclusion: Topical use of B. lactis HN019 promotes a protective effect against alveolar bone loss and CTAL sattributable to EP in rats, modifying immunoinflammatory and microbiologic parameters.
dc.description88
dc.description2
dc.description197
dc.description208
dc.descriptionSao Paulo Research Foundation (FAPESP) [2013/25022-7]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherAmer Acad Periodontology
dc.publisherChicago
dc.relationJournal of Periodontology
dc.rightsfechado
dc.sourceWOS
dc.subjectAlveolar Bone Loss
dc.subjectBifidobacterium
dc.subjectPeriodontal Attachment Loss
dc.subjectPeriodontitis
dc.subjectProbiotics
dc.subjectRats
dc.titleBenefits Of Bifidobacterium Animalis Subsp Lactis Probiotic In Experimental Periodontitis
dc.typeArtículos de revistas


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