Gwas Identifies New Loci For Painful Temporomandibular Disorder: Hispanic Community Health Study/study Of Latinos

dc.creatorSanders
dc.creatorA. E.; Jain
dc.creatorD.; Sofer
dc.creatorT.; Kerr
dc.creatorK. F.; Laurie
dc.creatorC. C.; Shaffer
dc.creatorJ. R.; Marazita
dc.creatorM. L.; Kaste
dc.creatorL. M.; Slade
dc.creatorG. D.; Fillingim
dc.creatorR. B.; Ohrbach
dc.creatorR.; Maixner
dc.creatorW.; Kocher
dc.creatorT.; Bernhardt
dc.creatorO.; Teumer
dc.creatorA.; Schwahn
dc.creatorC.; Sipila
dc.creatorK.; Lahdesmaki
dc.creatorR.; Mannikko
dc.creatorM.; Pesonen
dc.creatorP.; Jarvelin
dc.creatorM.; Rizzatti-Barbosa
dc.creatorC. M.; Meloto
dc.creatorC. B.; Ribeiro-Dasilva
dc.creatorM.; Diatchenko
dc.creatorL.; Serrano
dc.creatorP.; Smith
dc.creatorS. B.
dc.date2017
dc.datemar
dc.date2017-11-13T11:32:31Z
dc.date2017-11-13T11:32:31Z
dc.date.accessioned2018-03-29T05:47:09Z
dc.date.available2018-03-29T05:47:09Z
dc.identifierJournal Of Dental Research. Sage Publications Inc, v. 96, p. 277 - 284, 2017.
dc.identifier0022-0345
dc.identifier1544-0591
dc.identifierWOS:000398159100006
dc.identifier10.1177/0022034516686562
dc.identifierhttp://journals.sagepub.com.ez88.periodicos.capes.gov.br/doi/abs/10.1177/0022034516686562
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/326092
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1363098
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionTemporomandibular disorder (TMD) is a musculoskeletal condition characterized by pain and reduced function in the temporomandibular joint and/or associated masticatory musculature. Prevalence in the United States is 5% and twice as high among women as men. We conducted a discovery genome-wide association study (GWAS) of TMD in 10,153 participants (769 cases, 9,384 controls) of the US Hispanic Community Health Study/Study of Latinos (HCHS/SOL). The most promising single-nucleotide polymorphisms (SNPs) were tested in meta-analysis of 4 independent cohorts. One replication cohort was from the United States, and the others were from Germany, Finland, and Brazil, totaling 1,911 TMD cases and 6,903 controls. A locus near the sarcoglycan alpha (SGCA), rs4794106, was suggestive in the discovery analysis (P = 2.6 x 10(6)) and replicated (i.e., 1-tailed P = 0.016) in the Brazilian cohort. In the discovery cohort, sex-stratified analysis identified 2 additional genome-wide significant loci in females. One lying upstream of the relaxin/insulin-like family peptide receptor 2 (RXP2) (chromosome 13, rs60249166, odds ratio [OR] = 0.65, P = 3.6 x 10(-8)) was replicated among females in the meta-analysis (1-tailed P = 0.052). The other (chromosome 17, rs1531554, OR = 0.68, P = 2.9 x 10(-8))was replicated among females (1-tailed P = 0.002), as well as replicated in meta-analysis of both sexes (1-tailed P = 0.021). A novel locus at genome-wide level of significance (rs73460075, OR = 0.56, P = 3.8 x 10(-8)) in the intron of the dystrophin gene DMD (X chromosome), and a suggestive locus on chromosome 7 (rs73271865, P = 2.9 x 10(-7)) upstream of the Sp4 Transcription Factor (SP4) gene were identified in the discovery cohort, but neither of these was replicated. The SGCA gene encodes SGCA, which is involved in the cellular structure of muscle fibers and, along with DMD, forms part of the dystrophin-glycoprotein complex. Functional annotation suggested that several of these variants reside in loci that regulate processes relevant to TMD pathobiologic processes.
dc.description96
dc.description3
dc.description277
dc.description284
dc.descriptionNational Heart, Lung, and Blood Institute (NHLBI) [N01-HC65233]
dc.descriptionUniversity of Miami [N01-HC65234]
dc.descriptionAlbert Einstein College of Medicine [N01-HC65235]
dc.descriptionNorthwestern University [N01-HC 65236]
dc.descriptionSan Diego State University [N01-HC65237]
dc.descriptionNHLBI
dc.descriptionNIDCR [HHSN268201300005C AM03, MOD03, U01DE017018, HHSN268201200008I]
dc.descriptionNHLBI [HSN 26220/20054C]
dc.descriptionNCATS CTSI [UL1TR000124]
dc.descriptionNIDDK Diabetes Research Center (DRC) [DK063491]
dc.descriptionFederal Ministry of Education and Research [03ZIK012]
dc.descriptionSiemens Healthcare (Erlangen, Germany)
dc.descriptionFederal State of Mecklenburg-West Pomerania
dc.descriptionAcademy of Finland (Center of Excellence in Complex Disease Genetics) [104781, 120315, 129269, 1114194, 24300796]
dc.descriptionAcademy of Finland (SALVE)
dc.descriptionUniversity Hospital Oulu, Biocenter, University of Oulu [75617]
dc.descriptionNHLBI grant through the STAMPEED program [5R01HL087679-02, 1RL1MH083268-01]
dc.descriptionNIH/National Institute of Mental Health (NIMH) [5R01MH63706:02]
dc.descriptionENGAGE project [HEALTH-F4-2007-201413]
dc.descriptionEU FP7 EurHEALTH Ageing [277849]
dc.descriptionMedical Research Council (PrevMetSyn/SALVE) [G0500539, G0600705, G1002319]
dc.descriptionMRC, Centenary Early Career Award
dc.descriptionDynaHEALTH action [H2020-633595]
dc.descriptionAcademy of Finland EGEAproject [285547]
dc.descriptionAcademy of Finland
dc.descriptionBiocentrum Helsinki
dc.descriptionEuropean Commission (EURO-BLCS, Framework 5 award) [QLG1-CT-2000-01643]
dc.descriptionSigrid Juselius Foundation
dc.descriptionUS National Institute of Mental Health [5R01MH 63706:02]
dc.descriptionSao Paulo Research Foundation [2006/56019-8R, 2009/02520-6]
dc.descriptionCanadian Excellence Research Chairs (CERC) Program [CERC09]
dc.description[1R01DK101855-01]
dc.description[13GRNT1 6490017]
dc.description[rs117672662]
dc.description[R01 DK072193]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherSage Publications Inc
dc.publisherThousand Oaks
dc.relationJournal of Dental Research
dc.rightsfechado
dc.sourceWOS
dc.subjectEpidemiology
dc.subjectFunctional Annotation
dc.subjectPopulation
dc.subjectGenetics
dc.subjectHispanic Americans
dc.subjectMusculoskeletal Pain
dc.titleGwas Identifies New Loci For Painful Temporomandibular Disorder: Hispanic Community Health Study/study Of Latinos
dc.typeArtículos de revistas


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