Can Physical Exercise Have A Protective Effect In An Animal Model Of Sleep-related Movement Disorder?

dc.creatorEsteves
dc.creatorAndrea M.; Lopes
dc.creatorCleide; Frank
dc.creatorMiriam K.; Arida
dc.creatorRicardo M.; Frussa-Filho
dc.creatorRoberto; Tufik
dc.creatorSergio; de Mello
dc.creatorMarco Tulin
dc.date2016
dc.datemaio
dc.date2017-11-13T11:30:56Z
dc.date2017-11-13T11:30:56Z
dc.date.accessioned2018-03-29T05:45:59Z
dc.date.available2018-03-29T05:45:59Z
dc.identifierBrain Research. Elsevier Science Bv, v. 1639, p. 47 - 57, 2016.
dc.identifier0006-8993
dc.identifier1872-6240
dc.identifierWOS:000378447400005
dc.identifier10.1016/j.brainres.2016.02.036
dc.identifierhttp://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S0006899316300956
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/325828
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1362834
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThe purpose of the present study was to determine whether physical exercise (PE) has a protective effect in an experimental animal model of sleep-related movement disorder (All dopaminergic nuclei lesions with 6-OHDA). Rats were divided into four groups (Control PE-CTRL/PE, SHAM/PE, All lesion/NPE, All lesion/PE). Two experiments were performed: (1) the rats underwent PE before (2 weeks) and after (4 weeks) the All lesion; and (2) the rats underwent PE only after (4 weeks) the All lesion. Electrode insertion surgery was performed and sleep analyses were conducted over a period of 24 h (baseline and after PE) and analyzed in 6 blocks of 4 h. The results demonstrated that the All lesion produced an increased percentage of wakefulness in the final block of the dark period (37 am) and a significant enhancement of the number of limb movements (LM) throughout the day. Four weeks of PE was important for reducing the number of LMs in the All lesion group in the rats that performed PE before and after the All lesion. However, in the analysis of the protective effect of PE on LM, the results showed that the number of LMs was lower at baseline in the group that had performed 2 weeks of PE prior to the All lesion than in the group that had not previously performed PE. In conclusion, these findings consistently demonstrate that non-pharmacological manipulations had a beneficial effect on the symptoms of sleep-related movement disorder. (C) 2016 Elsevier B.V. All rights reserved.
dc.description1639
dc.description47
dc.description57
dc.descriptionAFIP (Associacao Fundo de Incentivo a Pesquisa)
dc.descriptionFAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [08/50646-6, 98/14303-3]
dc.descriptionCNPq (Conselho Nacional de Desenvolvimento Cientffico e Tecnologico)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageEnglish
dc.publisherElsevier Science BV
dc.publisherAmsterdam
dc.relationBrain Research
dc.rightsfechado
dc.sourceWOS
dc.subjectSleep Disorders
dc.subjectRestless Legs Syndrome
dc.subjectLimb Movement
dc.subjectPhysical Exercise
dc.titleCan Physical Exercise Have A Protective Effect In An Animal Model Of Sleep-related Movement Disorder?
dc.typeArtículos de revistas


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