Meloxicam As A Radiation-protective Agent On Mandibles Of Irradiated Rats

dc.creatorYamasaki
dc.creatorMayra Cristina; Roque-Torres
dc.creatorYuri Nejaim
dc.creatorGina Delia; Freitas
dc.creatorDeborah Queiroz
dc.date2017
dc.date2017-08-30T17:36:38Z
dc.date2017-08-30T17:36:38Z
dc.date.accessioned2018-03-29T05:29:14Z
dc.date.available2018-03-29T05:29:14Z
dc.identifierBrazilian Dental Journal. Fundação Odontológica De Ribeirão Preto, v. 28, n. 2, p. 249 - 255
dc.identifier0103-6440
dc.identifierS0103-64402017000200249
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402017000200249
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/324539
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1358757
dc.descriptionThis study evaluated the action of ionizing radiation and the possible radioprotective effect of the non-steroidal anti-inflammatory drug meloxicam on the bone physiology of rat mandibles by assessing the alveolar socket healing and bone strength. Forty male Wistar rats were divided in 4 groups (n=10): control (CG), irradiated (IG), meloxicam (MG), meloxicam irradiated (MIG). A dose of 0.2 mg/kg meloxicam was administered to MG and MIG. After this, IG and MIG were irradiated with 15 Gy radiation dose in the mandible. Forty days after the above procedures, the mandibular first molars were extracted and the animals were killed after 15 or 30 days (n=5). Micro-computed tomography and bending test were used to evaluate alveolar socket healing and bone strength, respectively. At 15 days, bone volume, bone volume fraction and trabecular thickness were higher in the CG and MG than in the IG and MIG; and trabecular separation was higher in the IG compared with the others. At 30 days, there was a difference only in trabecular separation, which was higher in IG than in CG and MG, and MIG did not differ from the others. Bone strength was lower in IG compared with CG and MG, and MIG did not differ from the others. In conclusion, the ionizing radiation affected the bone physiology of rat mandibles, delaying the alveolar socket healing and reducing the bone strength. Moreover, the meloxicam had a positive effect on the trabecular separation in alveolar socket healing and on the bone strength.
dc.description28
dc.description2
dc.description249
dc.description255
dc.languageIngles
dc.publisherFundação Odontológica de Ribeirão Preto
dc.relationBrazilian Dental Journal
dc.rightsaberto
dc.sourceScielo
dc.subjectIonizing Radiation
dc.subjectRadiation-protective Agents
dc.subjectNon-steroidal Anti-inflammatory Drugs.
dc.titleMeloxicam As A Radiation-protective Agent On Mandibles Of Irradiated Rats
dc.typeArtículos de revistas


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