Ultrasound-promoted Synthesis Of 3-(thiophen-2-yl)-4,5-dihydro-1h-pyrazole-1-carboximidamides And Anticancer Activity Evaluation In Leukemia Cell Lines

dc.creatorSantos
dc.creatorEric F. S. dos; Cury
dc.creatorNathália M.; Nascimento
dc.creatorTainara A. do; Raminelli
dc.creatorCristiano; Casagrande
dc.creatorGleison A.; Pereira
dc.creatorClaudio M. P.; Simionatto
dc.creatorEuclésio; Yunes
dc.creatorJosé A.; Pizzuti
dc.creatorLucas
dc.date2017
dc.date2017-08-30T17:36:30Z
dc.date2017-08-30T17:36:30Z
dc.date.accessioned2018-03-29T05:29:02Z
dc.date.available2018-03-29T05:29:02Z
dc.identifierJournal Of The Brazilian Chemical Society. Sociedade Brasileira De Química, v. 28, n. 2, p. 217 - 224
dc.identifier0103-5053
dc.identifierS0103-50532017000200217
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532017000200217&lng=pt&nrm=iso&tlng=en
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/324491
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1358709
dc.description3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides were efficiently prepared through a cyclocondensation of thiophenylchalcones with aminoguanidine hydrochloride under ultrasonic conditions in the presence of KOH and ethanol as a green solvent in short reaction times (15-35 min) and good yields (62-95%). All compounds produced were evaluated against the human Jurkat and RS4;11 acute lymphoblastic leukemia cell lines of T- and B-cell origin, respectively, and the K562 myelogenous leukemia cell line. Six compounds presented half maximal inhibitory concentration (IC50) values around 15 µmol L-1 and five compounds presented IC50 values around 40 µmol L-1 for at least one of the three cell lines analyzed. One compound was not significantly cytotoxic, presenting IC50 value > 100 µmol L-1.
dc.description28
dc.description2
dc.description217
dc.description224
dc.languageIngles
dc.publisherSociedade Brasileira de Química
dc.relationJournal of the Brazilian Chemical Society
dc.rightsaberto
dc.sourceScielo
dc.subjectAmidinopyrazole
dc.subjectPyrazoline
dc.subjectCytotoxic Activity
dc.subjectLeukemia
dc.subjectUltrasonic Irradiation
dc.titleUltrasound-promoted Synthesis Of 3-(thiophen-2-yl)-4,5-dihydro-1h-pyrazole-1-carboximidamides And Anticancer Activity Evaluation In Leukemia Cell Lines
dc.typeArtículos de revistas


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