Mast Cells Distinguish Eosinophilic Esophagitis In Pediatric Patients

Mastócitos Discriminam Esofagite Eosinofílica Em Pacientes Pediátricos

dc.creatorLomazi
dc.creatorElizete Aparecida; Brandalise
dc.creatorNelson Ary; Servidoni
dc.creatorMaria de Fátima Pimenta Correa; Cardoso
dc.creatorSilvia Regina; Meirelles
dc.creatorLuciana Rodrigues
dc.date2017
dc.date2017-08-30T17:36:05Z
dc.date2017-08-30T17:36:05Z
dc.date.accessioned2018-03-29T05:28:29Z
dc.date.available2018-03-29T05:28:29Z
dc.identifierArquivos De Gastroenterologia. Instituto Brasileiro De Estudos E Pesquisas De Gastroenterologia - Ibepege Colégio Brasileiro De Cirurgia Digestiva - Cbcd Sociedade Brasileira De Motilidade Digestiva E Neurogastroenterologia - Sbmdn Federação Brasileira De Gastroenterologia - Fbgsociedade Brasileira De Hepatologia - Sbhsociedade Brasileira De Endoscopia Digestiva - Sobed, p.
dc.identifier0004-2803
dc.identifierS0004-28032017005004105
dc.identifierhttp://www.scielo.br/scielo.php?pid=S0004-28032017005004105&script=sci_arttext
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/324360
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1358578
dc.descriptionMast cells exert a substantial role in gastrointestinal allergic diseases. Therefore, it is reasonable to presume that mast cell may aid diagnosis in eosinophilic gastroenteropathy. OBJECTIVE: To evaluate whether mast cell count in the esophageal epithelium can discriminate eosinophilic esophagitis, proton-pump inhibitor (PPI)-responsive eosinophilic esophagitis and gastroesophageal reflux esophagitis. METHODS: Retrospectively we reviewed the files of 53 consecutive patients (age: 7.8 years; range: 8-14 years) with definitive diagnose established during clinical follow up in a universitary outpatient clinic as follow: eosinophilic esophagitis (N=23), PPI-responsive eosinophilic esophagitis (N=15) and gastroesophageal reflux esophagitis (N=15). Eosinophil count in the esophageal epithelium in slides stained with H-E was reviewed and immunohistochemistry for mast cell tryptase was performed. RESULTS: Count of eosinophils/high-power field (HPF) higher than 15 were found in 14 out of 15 reflux esophagitis patients. The mean count of eosinophils/HPF was similar in eosinophilic esophagitis patients and in those with PPI-responsive eosinophilic esophagitis (42 and 39 eosinophils/HPF, respectively, P=0.47). Values of mast cell tryptase (+) were higher in eosinophilic esophagitis [median: 25 mast cells/HPF; range (17-43) ] and in PPI-responsive eosinophilic esophagitis patients [25 (16-32) ], compared to reflux esophagitis [4 (2-14) ], P<0.001. There was no difference between the mean count of mast cells/HPF in the esophageal epithelium of eosinophilic esophagitis patients and PPI-responsive eosinophilic esophagitis patients, respectively, 26 and 24 mast cells/HPF, P=0.391. CONCLUSION: Tryptase staining of mast cells differentiates eosinophilic esophagitis from reflux esophagitis.
dc.languageIngles
dc.publisherInstituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva e Neurogastroenterologia - SBMDN Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBED
dc.relationArquivos de Gastroenterologia
dc.rightsaberto
dc.sourceScielo
dc.subjectEsophageal Diseases
dc.subjectEosinophilic Esophagitis
dc.subjectPeptic Esophagitis
dc.subjectMast Cells
dc.subjectImmunohistochemistry
dc.subjectDoenças Do Esôfago
dc.subjectEsofagite Eosinofílica
dc.subjectEsofagite Peptic
dc.subjectMastócitos
dc.subjectImuno-histoquímica
dc.titleMast Cells Distinguish Eosinophilic Esophagitis In Pediatric Patients
dc.titleMastócitos Discriminam Esofagite Eosinofílica Em Pacientes Pediátricos
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución