Brasil | Artículos de revistas

Vitamin B-6 Status In Unsupplemented Pregnant Women Is Associated Positively With Serum Docosahexaenoic Acid And Inversely With The N-6-to-n-3 Fatty Acid Ratio

dc.creatorMujica-Coopman M.F.
dc.creatorFranco-Sena A.B.
dc.creatorFarias D.R.
dc.creatorVaz J.S.
dc.creatorBrito A.
dc.creatorKac G.
dc.creatorLamers Y.
dc.date2017
dc.date2017-08-17T19:17:57Z
dc.date2017-08-17T19:17:57Z
dc.date.accessioned2018-03-29T05:27:44Z
dc.date.available2018-03-29T05:27:44Z
dc.identifierJournal Of Nutrition. American Society For Nutrition, v. 147, n. 2, p. 170 - 178, 2017.
dc.identifier0022-3166
dc.identifier10.3945/jn.116.239483
dc.identifierhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85012074580&doi=10.3945%2fjn.116.239483&partnerID=40&md5=26d7272ed86112254a396219d9fde1bf
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/324238
dc.identifier2-s2.0-85012074580
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1358401
dc.descriptionBackground: Vitamin B-6-deficient diets decrease plasma docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and arachidonic acid (AA) concentrations in healthy adults. These fatty acids (FAs) are important for fetal neurodevelopment, but the relation between vitamin B-6 status and circulating polyunsaturated FAs (PUFAs) during pregnancy is unknown. Objective: We sought to assess the relation between plasma pyridoxal 5' phosphate (PLP; the active form of vitamin B-6) and serum DHA, EPA, AA, linoleic acid, eicosadienoic, and a-linolenic acid concentrations during pregnancy. Methods: A prospective cohort study in 186 healthy pregnant Brazilian women (aged 20-40 y) who were not using supplements was conducted in Rio de Janeiro, Brazil. Participants were enrolled in the first trimester of pregnancy (5-13 gestational weeks) and were followed up twice between 20-26 and 30-36 wk of gestation. Longitudinal linear mixed-effects regression models were used to evaluate the associations between 1) first-trimester PLP and PUFA concentrations across pregnancy and 2) ΔPLP (i.e., difference between third- and first-trimester plasma PLP concentrations) and PUFA concentrations across pregnancy. Models were adjusted for gestational week, first-trimester body mass index, smoking habit, and dietary intakes of vitamin B-6, fish, total fat, and PUFAs. Results: Plasma PLP concentrations (median, IQR) substantially declined during pregnancy from 35.8 nmol/L (28.6-44.3 nmol/L) in the first trimester to 21.0 nmol/L (15.8-26.3 nmol/L) in the second trimester, and 16.8 nmol/L (12.9-20.3 nmol/L) in the third trimester (both P < 0.0001). Changes in plasma PLP concentrations across trimesterswere positively associated with serum DHA concentrations (β = 0.252, P = 0.012) and inversely associatedwith serumn-6-to-n-3 (ω-6-to-ω-3) FA ratio (b =20.010; P = 0.015), after adjustments for confounders. Conclusions: Maternal vitamin B-6 status during pregnancywas positively associated with the circulating concentration of DHA and inversely associated with n-6:n-3 FAs in Brazilian women who were not taking vitamin supplements. Further study is required to determine the impact of poor vitamin B-6 status on fetal neurodevelopment. © 2017 American Society for Nutrition.
dc.description147
dc.description2
dc.description170
dc.description178
dc.languageEnglish
dc.publisherAmerican Society for Nutrition
dc.relationJournal of Nutrition
dc.rightsfechado
dc.sourceScopus
dc.subjectDha
dc.subjectDocosahexaenoic Acid
dc.subjectEicosapentaenoic Acid
dc.subjectEpa
dc.subjectN-3 Fatty Acids
dc.subjectPolyunsaturated Fatty Acid
dc.subjectPregnancy
dc.subjectPufa
dc.subjectPyridoxal 5'-phosphate
dc.subjectVitamin B-6
dc.titleVitamin B-6 Status In Unsupplemented Pregnant Women Is Associated Positively With Serum Docosahexaenoic Acid And Inversely With The N-6-to-n-3 Fatty Acid Ratio
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución