Recent Advances In Genetic Manipulation Of Organisms For The Production Of Nonribosomal Peptides

Avanços Recentes Na Manipulação Genética De Organismos Para A Produção De Peptídeos Não Ribossomais

dc.creatorGonzález G.D.T.
dc.creatorSigrist R.
dc.creatorPaulo B.S.
dc.date2016
dc.date2017-08-17T19:15:53Z
dc.date2017-08-17T19:15:53Z
dc.date.accessioned2018-03-29T05:22:40Z
dc.date.available2018-03-29T05:22:40Z
dc.identifierRevista Virtual De Quimica. Secretaria Regional Do Rio De Janeiro Da Sociedade Brasileira De Quimica, v. 8, n. 6, p. 1998 - 2025, 2016.
dc.identifier1984-6835
dc.identifier10.21577/1984-6835.20160135
dc.identifierhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85010661906&doi=10.21577%2f1984-6835.20160135&partnerID=40&md5=fa9001222a96de8c772d0a8c5e431b5b
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/323921
dc.identifier2-s2.0-85010661906
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1358084
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionNonribosomal peptides (NRP) are a class of natural products biosynthesized by nonribosomal peptide synthetases (NRPS). These complex multimodular enzymes are present mainly in bacteria and filamentous fungi and each module is responsible for substrates insertion, elongation and chemical modification of the NRP chain. NRP are polypeptides with broad biological activity and the antibiotic property is of especial interest to the pharmaceutical industries in order to fight against one of the biggest challenges of modern medicine: bacterial multiresistance to current available drugs. Over the last years, the NRP biosynthesis have been studied and engineered in order to obtain structural diversity. The advances in molecular biology in the post-genomic era assured the enhancement of already known techniques, such as site-directed mutation, increasing the promiscuity of enzymes, furthermore the introduction of new techniques, as heterologous expression, complete transference of gene clusters to heterologous organisms allowed the identification of new compounds or increasing expression level of already identified products. The present review aims to highlight the relevance of mutasynthesis and heterologous expression for the production of new natural products biosynthesized by NRPS.
dc.description8
dc.description6
dc.description1998
dc.description2025
dc.descriptionCAPES, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description130933/2015-5, CNPq, Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description2015-010134, FAPESP, Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languagePortuguese
dc.publisherSecretaria Regional do Rio de Janeiro da Sociedade Brasileira de Quimica
dc.relationRevista Virtual de Quimica
dc.rightsfechado
dc.sourceScopus
dc.subjectHeterologous Expression
dc.subjectMutasynthesis
dc.subjectNonribossomal Peptide Synthetases
dc.subjectNonribossomal Peptides
dc.titleRecent Advances In Genetic Manipulation Of Organisms For The Production Of Nonribosomal Peptides
dc.titleAvanços Recentes Na Manipulação Genética De Organismos Para A Produção De Peptídeos Não Ribossomais
dc.typeArtículos de revistas


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