Spontaneous Experimental Atherosclerosis In Hypercholesterolemic Mice Advances With Ageing And Correlates With Mitochondrial Reactive Oxygen Species

dc.creatorDorighello G.G.
dc.creatorPaim B.A.
dc.creatorLeite A.C.R.
dc.creatorVercesi A.E.
dc.creatorOliveira H.C.F.
dc.date2016
dc.date2017-08-17T19:15:23Z
dc.date2017-08-17T19:15:23Z
dc.date.accessioned2018-03-29T05:21:57Z
dc.date.available2018-03-29T05:21:57Z
dc.identifierExperimental Gerontology. Elsevier Inc., p. , 2016.
dc.identifier0531-5565
dc.identifier10.1016/j.exger.2017.02.010
dc.identifierhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85013455555&doi=10.1016%2fj.exger.2017.02.010&partnerID=40&md5=a8726425a5e897061fed791a143dc53b
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/323746
dc.identifier2-s2.0-85013455555
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1357909
dc.descriptionAgeing and atherosclerosis are associated with oxidative stress. Mitochondrial redox function declines with ageing. Here we tested whether ageing LDL receptor knockout mice (LDLr-/-) develop spontaneous atherosclerosis and whether mitochondrial reactive oxygen species (mtROS) correlate with atherosclerosis. Compared with young mice, aged LDLr-/- mice exhibited 20-fold larger aortic lesion size, although the plasma cholesterol levels did not vary between age groups. The lesion sizes increased exponentially from 3 to 24months of age (r=0.92, p=0.0001) and were correlated with mtROS across the age range (r=0.81, p=0.0001). Thus, LDLr-/- mice develop spontaneous diet-independent atherosclerosis, that advances exponentially with ageing. We propose that age related increases in mtROS contribute to accelerate atherosclerosis development in hypercholesterolemic mice. © 2017 Elsevier Inc.
dc.languageEnglish
dc.publisherElsevier Inc.
dc.relationExperimental Gerontology
dc.rightsfechado
dc.sourceScopus
dc.subjectAtherosclerosis
dc.subjectHypercholesterolemia
dc.subjectLdl Receptor
dc.subjectMitochondria
dc.subjectReactive Oxygen
dc.titleSpontaneous Experimental Atherosclerosis In Hypercholesterolemic Mice Advances With Ageing And Correlates With Mitochondrial Reactive Oxygen Species
dc.typeArtículos de revistas


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