Efficacy Of Continuous S(+)-ketamine Infusion For Postoperative Pain Control: A Randomized Placebo-controlled Trial

dc.creatorMiziara
dc.creatorLEDG; Simoni
dc.creatorRF; Esteves
dc.creatorLO; Cangiani
dc.creatorLH; Grillo
dc.creatorGFR; Paula
dc.creatorAGLE
dc.date2016
dc.date2016-12-06T18:31:57Z
dc.date2016-12-06T18:31:57Z
dc.date.accessioned2018-03-29T02:04:32Z
dc.date.available2018-03-29T02:04:32Z
dc.identifier1687-6970
dc.identifierAnesthesiology Research And Practice. HINDAWI PUBLISHING CORP, n. 6918327, p. .
dc.identifier1687-6962
dc.identifierWOS:000370267900001
dc.identifier10.1155/2016/6918327
dc.identifierhttps://www.hindawi.com/journals/arp/2016/6918327/abs/
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/320415
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1311181
dc.descriptionAim. A double-blind, randomized, placebo-controlled trial was designed to evaluate the efficacy of continuous intraoperative infusion of S(+)-ketamine under intravenous anesthesia with target-controlled infusion of remifentanil and propofol for postoperative pain control. Methods. Forty-eight patients undergoing laparoscopic cholecystectomy were assigned to receive continuous S(+)-ketamine infusion at a rate of 0.3mg.kg(-1).h(-1) (n = 24, intervention group) or an equivalent volume of saline at the same rate (n = 24, placebo group). The same target-controlled intravenous anesthesia was induced in both groups. Pain was assessed using a 0 to 10 verbal numeric rating scale during the first 12 postoperative hours. Pain scores and morphine consumption were recorded in the postanesthesia care unit (PACU) and at 4 and 12 hours after surgery. Results. Pain scores were lower in the intervention group at all time points. Morphine consumption did not differ significantly between groups during PACU stay, but it was significantly lower in the intervention group at each time point after PACU discharge (P = 0.0061). At 12 hours after surgery, cumulative morphine consumption was also lower in the intervention group (5.200 +/- 2.707) than in the placebo group (7.525 +/- 1.872). Conclusions. Continuous S(+)-ketamine infusion during laparoscopic cholecystectomy under target-controlled intravenous anesthesia provided better postoperative pain control than placebo, reducing morphine requirement. Trial Registration. This trial is registered with ClinicalTrials.gov NCT02421913.
dc.description
dc.description
dc.description
dc.description
dc.description
dc.description
dc.description
dc.languageEnglish
dc.publisherHINDAWI PUBLISHING CORP
dc.publisherNEW YORK
dc.relationAnesthesiology Research and Practice
dc.rightsaberto
dc.sourceWOS
dc.subject:d-aspartate Receptor
dc.subjectMu-opioid Receptor
dc.subjectDorsal-horn
dc.subjectTyrosine Phosphorylation
dc.subjectInduced Hyperalgesia
dc.subjectRemifentanil
dc.subjectKetamine
dc.subjectTolerance
dc.subjectHumans
dc.subjectPotentiation
dc.titleEfficacy Of Continuous S(+)-ketamine Infusion For Postoperative Pain Control: A Randomized Placebo-controlled Trial
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución