Phema Hydrogels Synthesis, Kinetics And In Vitro Tests

dc.creatorPassos
dc.creatorMF; Dias
dc.creatorDRC; Bastos
dc.creatorGNT; Jardini
dc.creatorAL; Benatti
dc.creatorACB; Dias
dc.creatorCGBT; Maciel
dc.creatorR
dc.date2016
dc.date2016-12-06T18:31:20Z
dc.date2016-12-06T18:31:20Z
dc.date.accessioned2018-03-29T02:03:58Z
dc.date.available2018-03-29T02:03:58Z
dc.identifier1572-8943
dc.identifierJournal Of Thermal Analysis And Calorimetry. SPRINGER, n. 125, n. 1, p. 361 - 368.
dc.identifier1388-6150
dc.identifierWOS:000377790200035
dc.identifier10.1007/s10973-016-5329-6
dc.identifierhttp://link.springer.com/article/10.1007/s10973-016-5329-6
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/320276
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1311042
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionHydrogels of poly (2-hydroxyethyl methacrylate) (pHEMA) are suitable materials for medical applications. Synthesis, structural characterization, kinetic, physical properties and cell viability of these materials are reported in this article. The system was conducted via free radical polymerization in the absence of solvents or cross-linking agents. Hydrogels were obtained with excellent dimensional stability and high thermal stability (738 K), glass transition temperature of approximately 375 K and a degree of swelling of 66 +/- A 4 % in ethanol. The conversion of C=C double bond of the monomer 2-hydroxyethyl methacrylate was confirmed by Fourier transform infrared spectroscopy. Results showed dense and rough morphologies in the pHEMA, presence of high molecular interactions and good resistance to various organic solvents. In vitro tests showed excellent cell viability. The materials did not display cytotoxicity, and cells proliferated and adhered at a satisfactory rate on the hydrogel. These materials have great potential for biomedical application. pHEMA hydrogels are materials receiving great attention among researchers due to their ease of synthesis and biomedical application. This article demonstrates a new method of obtaining pHEMA hydrogels by bulk polymerization, in a single processing step and without the use of cross-linking agents. A kinetic study was evaluated, and the results of in vitro tests showed good cell proliferation. [GRAPHICS] .
dc.description125
dc.description
dc.description361
dc.description368
dc.descriptionSao Paulo Research Foundation (FAPESP) [2008/57860-3, 2011/18525-7]
dc.descriptionNational Institute of Science and Technology in Biofabrication (BIOFABRIS)
dc.descriptionNational Council of Technological and Scientific Development (CNPq) [573661/2008-1]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description
dc.description
dc.description
dc.languageEnglish
dc.publisherSPRINGER
dc.publisherDORDRECHT
dc.relationJournal of Thermal Analysis and Calorimetry
dc.rightsfechado
dc.sourceWOS
dc.subjectPhema
dc.subjectHydrogel
dc.subjectBiomaterial
dc.subjectCalorimetry
dc.subjectKinetic
dc.subjectIn Vitro Tests
dc.titlePhema Hydrogels Synthesis, Kinetics And In Vitro Tests
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución