Multiple Structure Single Parameter: Analysis Of A Single Protein Nano Environment Descriptor Characterizing A Shared Loci On Structurally Aligned Proteins

dc.creatorSalim
dc.creatorJA; Borro
dc.creatorL; Mazoni
dc.creatorI; Yano
dc.creatorI; Jardine
dc.creatorJG; Neshich
dc.creatorG
dc.date2016
dc.date2016-12-06T18:31:19Z
dc.date2016-12-06T18:31:19Z
dc.date.accessioned2018-03-29T02:03:57Z
dc.date.available2018-03-29T02:03:57Z
dc.identifier1460-2059
dc.identifierBioinformatics. OXFORD UNIV PRESS, n. 32, n. 12, p. 1885 - 1887.
dc.identifier1367-4803
dc.identifierWOS:000379734300061
dc.identifier10.1093/bioinformatics/btw082
dc.identifierhttps://academic.oup.com/bioinformatics/article-lookup/doi/10.1093/bioinformatics/btw082
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/320271
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1311037
dc.descriptionMotivation: A graphical representation of physicochemical and structural descriptors attributed to amino acid residues occupying the same topological position in different, structurally aligned proteins can provide a more intuitive way to associate possible functional implications to identified variations in structural characteristics. This could be achieved by observing selected characteristics of amino acids and of their corresponding nano environments, described by the numerical value of matching descriptor. For this purpose, a web-based tool called multiple structure single parameter (MSSP) was developed and here presented. Results: MSSP produces a two-dimensional plot of a single protein descriptor for a number of structurally aligned protein chains. From a total of 150 protein descriptors available in MSSP, selected of >1500 parameters stored in the STING database, it is possible to create easily readable and highly informative XY-plots, where X-axis contains the amino acid position in the multiple structural alignment, and Y-axis contains the descriptor's numerical values for each aligned structure. To illustrate one of possible MSSP contributions to the investigation of changes in physicochemical and structural properties of mutants, comparing them with the cognate wild-type structure, the oncogenic mutation of M918T in RET kinase is presented. The comparative analysis of wild-type and mutant structures shows great changes in their electrostatic potential. These variations are easily depicted at the MSSP-generated XY-plot.
dc.description32
dc.description
dc.description1885
dc.description1887
dc.descriptionBrazilian Agricultural Research Corporation (EMBRAPA)
dc.description
dc.description
dc.description
dc.languageEnglish
dc.publisherOXFORD UNIV PRESS
dc.publisherOXFORD
dc.relationBioinformatics
dc.rightsfechado
dc.sourceWOS
dc.subjectAlignment
dc.subjectAlgorithm
dc.titleMultiple Structure Single Parameter: Analysis Of A Single Protein Nano Environment Descriptor Characterizing A Shared Loci On Structurally Aligned Proteins
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución