Semaphorins And Neuropilins Expression In Salivary Gland Tumors

dc.creatorFonseca
dc.creatorFP; Bingle
dc.creatorL; Santos-Silva
dc.creatorAR; Lopes
dc.creatorMA; de Almeida
dc.creatorOP; de Andrade
dc.creatorBAB; Mariano
dc.creatorFV; Kowalski
dc.creatorLP; Rangel
dc.creatorALCA; Martins
dc.creatorMD; Meurer
dc.creatorL; Speight
dc.creatorPM; Vargas
dc.creatorPA
dc.date2016
dc.date2016-12-06T18:30:37Z
dc.date2016-12-06T18:30:37Z
dc.date.accessioned2018-03-29T02:03:11Z
dc.date.available2018-03-29T02:03:11Z
dc.identifier1600-0714
dc.identifierJournal Of Oral Pathology & Medicine. WILEY-BLACKWELL, n. 45, n. 2, p. 119 - 126.
dc.identifier0904-2512
dc.identifierWOS:000369988600007
dc.identifier10.1111/jop.12341
dc.identifierhttp://onlinelibrary-wiley-com.ez88.periodicos.capes.gov.br/doi/10.1111/jop.12341/abstract
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/320079
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1310845
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionSalivary gland tumors (SGT) account for 3-10% of all head and neck neoplasms, and little is known about their angiogenic properties. Despite semaphorins and neuropilins have been demonstrated to be prognostic determinants in many human cancers, they remain to be investigated in SGT. Therefore, the objective of this study was to analyze the clinical significance of the expression of class 3 semaphorins A (Sema3A) and B (Sema3B) and neuropilins-1 (Np-1) and neuropilins-2 (Np-2), in SGT. MethodsTwo hundred and forty-eight SGT were organized in tissue microarray paraffin blocks and expression of CD34, Sema3A, Sema3B, Np-1, and Np-2 was determined through immunohistochemistry. The immunoreactions were quantified using digital algorithms and the results correlated with clinicopathological parameters. ResultsMalignant tumors had an increased vascular density than their benign counterparts and their increased vascular area significantly correlated with recurrences (P<0.05). Patients older than 40years and the presence of recurrences determined an inferior survival rate (P=0.0057 and P=0.0303, respectively). In normal salivary glands, Np-1 and Np-2 expression was restricted to ductal cells, whereas Sema3A and Sema3B were positive in the serous acinar compartment. Tumors were positive for all markers and the co-expression of Np-1/Np-2 significantly correlated with the presence of paresthesia and advanced stages of the tumors (P=0.01 and P=0.04, respectively). ConclusionSema3A, Sema3B, Np-1, and Np-2 may be involved in the pathogenesis of SGT, but their expression did not present a statistically significant prognostic potential in this study.
dc.description45
dc.description
dc.description119
dc.description126
dc.descriptionSao Paulo State Research Foundation (Brazil) [2009/53839-2, 2012/07519-9, 2012/10781-7]
dc.descriptionBrazilian Coordination of Higher Education [CAPES/PDSE 2892/13-8]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description
dc.description
dc.description
dc.languageEnglish
dc.publisherWILEY-BLACKWELL
dc.publisherHOBOKEN
dc.relationJournal of Oral Pathology & Medicine
dc.rightsfechado
dc.sourceWOS
dc.subjectCd34
dc.subjectNeuropilins
dc.subjectPrognosis
dc.subjectSalivary Gland Neoplasms
dc.subjectSemaphorins
dc.titleSemaphorins And Neuropilins Expression In Salivary Gland Tumors
dc.typeArtículos de revistas


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