Prolactin, Egfr, Vimentin And Alpha-actin Profiles In Elderly Rat Prostate Subjected To Steroid Hormonal Imbalance

dc.creatorHetzl
dc.creatorAC; Montico
dc.creatorF; Kido
dc.creatorLA; Cagnon
dc.creatorVHA
dc.date2016
dc.date2016-12-06T18:29:35Z
dc.date2016-12-06T18:29:35Z
dc.date.accessioned2018-03-29T02:02:07Z
dc.date.available2018-03-29T02:02:07Z
dc.identifier
dc.identifierTissue & Cell. CHURCHILL LIVINGSTONE, n. 48, n. 3, p. 189 - 196.
dc.identifier1532-3072
dc.identifierWOS:000376396200006
dc.identifier10.1016/j.tice.2016.03.008
dc.identifierhttp://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S0040816615300124
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/319811
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1310577
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThe aim of this study was to characterize and relate the prolactin (PR), epidermal growth factor receptor (EGFR), alpha-actin and vimentin immunoreactivity in the prostate of elderly rats subjected to steroid hormonal imbalance. Senile and young rats were divided into the young group (YNG), the senile group (SE), the castrated group (CAS), the estrogen-deficient group (ED), the castrated + estrogen group (CASE), and the estrogen-deficient + androgen group (EDTEST). PR and EGFR increased in the estrogen and androgen ablation groups. In addition, EGFR influenced the immunolocalization by changing it from the prostatic stroma to the epithelium in elderly rats. Hormone ablation in elderly rats, not only related to androgen but also estrogen, led to increased stromal EGFR immunolocalization. The alpha-actin pattern decreased in the groups with estrogenic imbalance. Moreover, vimentin increased in the senile and estrogen deficient group. To conclude, we can suggest that EGFR contributed towards the proliferative process in the prostate, by means however, of different mechanisms, considering the androgenic and estrogenic pathways. Also, our results indicated that prolactin could be activated not only in an androgen-independent pathway but also in an estrogen independent pathway. Finally, PR and vimentin immunolocalization increase, in the prostatic stroma in the group showing estrogenic ablation, could be one of the factors which contribute to the reactive stroma formation. (C) 2016 Elsevier Ltd. All rights reserved.
dc.description48
dc.description
dc.description189
dc.description196
dc.descriptionSao Paulo Research Foundation (FAPESP) [2010/01739-1, 2009/50396-2]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description
dc.description
dc.description
dc.languageEnglish
dc.publisherCHURCHILL LIVINGSTONE
dc.publisherEDINBURGH
dc.relationTissue & Cell
dc.rightsfechado
dc.sourceWOS
dc.subjectProstate
dc.subjectRat
dc.subjectProlactin
dc.subjectEgfr
dc.subjectVimentin And Alpha-actin
dc.titleProlactin, Egfr, Vimentin And Alpha-actin Profiles In Elderly Rat Prostate Subjected To Steroid Hormonal Imbalance
dc.typeArtículos de revistas


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