Characterization and evaluation of the cytotoxic potential of the essential oil of Chenopodium ambrosioides

dc.creatorDegenhardt
dc.creatorRuth T.; Farias
dc.creatorIngrid V.; Grassi
dc.creatorLiliane T.; Franchi Jr.
dc.creatorGilberto C.; Nowill
dc.creatorAlexandre E.; Bittencourt
dc.creatorChristiane M. da S.; Wagner
dc.creatorTheodoro M.; Souza
dc.creatorMarcia M. de; Cruz
dc.creatorAlexandre Bella; Malheiros
dc.creatorAngela
dc.date2016
dc.date2016-11-10T19:23:12Z
dc.date2016-11-10T19:23:12Z
dc.date.accessioned2018-03-29T01:59:58Z
dc.date.available2018-03-29T01:59:58Z
dc.identifierRevista Brasileira De Farmacognosia, 26, 1, p.56-. 2016.
dc.identifier1981-528X
dc.identifierS0102-695X2016000100056
dc.identifier10.1016/j.bjp.2015.08.012
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000100056
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/319126
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1310007
dc.descriptionThe essential oil of Chenopodium ambrosioides L., Amaranthaceae, was obtained by steam distillation in a Clevenger apparatus and characterization was performed using chromatographic and spectroscopic assays (GC-FID, GC/MS, 1H NMR). Two major compounds were identified: p-cymene (42.32%) and ascaridole (49.77%). The ethanolic extract and hydrolate were fractionated by liquid liquid partitioning and the compounds were characterized by GC/MS. The essential oil, ethanol extract and fractions by partitioning with dicloromethane, ethyl acetate and butanol were tested in tumor cell lines (K562, NALM6, B15, and RAJI). Significant cytotoxic activity was found for essential oil (IC50 = 1.0 µg/ml) for RAJI cells and fraction dicloromethane (IC50 = 34.0 µg/ml) and ethanol extract (IC50 = 47.0 µg/ml) for K562 cells. The activity of the essential oil of C. ambrosioides is probably related to the large amount of ascaridol, since the other major compound, p-cymene, is recognized as a potent anti-inflammatory and has low cytotoxic activity.
dc.description
dc.description26
dc.description1
dc.description56
dc.description61
dc.languageEnglish
dc.relationRevista Brasileira de Farmacognosia
dc.relationRevista Brasileira de Farmacognosia
dc.rightsaberto
dc.sourceSciELO
dc.titleCharacterization and evaluation of the cytotoxic potential of the essential oil of Chenopodium ambrosioides
dc.title
dc.typeArtículos de revistas


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