Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features

dc.creatorde Oliveira, Jaqueline Carvalho
dc.creatorScrideli, Carlos Alberto
dc.creatorBrassesco, Maria Sol
dc.creatorMorales, Andressa Gois
dc.creatorPezuk, Julia Alejandra
dc.creatorQueiroz, Rosane de Paula
dc.creatorYunes, Jose Andres
dc.creatorBrandalise, Silvia Regina
dc.creatorTone, Luiz Gonzaga
dc.date2012
dc.date2013-09-19T18:06:28Z
dc.date2016-07-01T15:47:29Z
dc.date2013-09-19T18:06:28Z
dc.date2016-07-01T15:47:29Z
dc.date.accessioned2018-03-29T01:56:15Z
dc.date.available2018-03-29T01:56:15Z
dc.identifierLeukemia Research. Pergamon-Elsevier Science Ltd, v.36, n.3, p.293-298, 2012
dc.identifier0145-2126
dc.identifierWOS:000299316700013
dc.identifier10.1016/j.leukres.2011.10.005
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2174
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2174
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1309001
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThe present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of childhood acute lymphoblastic leukemia (ALL) by quantitative real-time PCR. A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL. These findings suggest a potential activity of these microRNAs in pediatric ALL biology. (C) 2011 Elsevier Ltd. All rights reserved.
dc.description36
dc.description3
dc.description293
dc.description298
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAEPA (Brazil)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherPergamon-Elsevier Science Ltd
dc.publisherOxford
dc.relationLeukemia Research
dc.rightsfechado
dc.sourceWOS
dc.subjectMicroRNA
dc.subjectPediatric acute lymphoblastic leukemia
dc.subjectPrognostic features
dc.subjectMINIMAL-RESIDUAL-DISEASE
dc.subjectLUNG-CANCER CELLS
dc.subjectTHERAPEUTIC TARGETS
dc.subjectMICRORNA EXPRESSION
dc.subjectMICROARRAY ANALYSIS
dc.subjectDRUG-RESISTANCE
dc.subjectOVARIAN-CANCER
dc.subjectUP-REGULATION
dc.subjectCARCINOMA
dc.subjectMIR-196B
dc.titleDifferential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features
dc.typeArtículos de revistas


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