Allergenicity of Bos d 5 in Children with Cow's Milk Allergy is Reduced by Transglutaminase Polymerization

dc.creatorOlivier, Celso Eduardo
dc.creatorVillas-Boas, Mariana Battaglin
dc.creatorNetto, Flavia Maria
dc.creatorZollner, Ricardo de Lima
dc.date2012
dc.date2013-09-19T18:06:23Z
dc.date2016-07-01T15:40:43Z
dc.date2013-09-19T18:06:23Z
dc.date2016-07-01T15:40:43Z
dc.date.accessioned2018-03-29T01:56:03Z
dc.date.available2018-03-29T01:56:03Z
dc.identifierPediatric Allergy Immunology and Pulmonology. Mary Ann Liebert Inc, v.25, n.1, p.30-33, 2012
dc.identifier2151-321X
dc.identifierWOS:000302282600006
dc.identifier10.1089/ped.2011.0101
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2110
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2110
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308951
dc.descriptionBackground: Cow's milk allergy in pediatric patients is an unresolved issue. Among the proteins in milk, bovine whey beta-lactoglobulin (Bos d 5) is the most commonly allergenic. Allergenicity to native cow's milk proteins in humans is a well-studied issue, but very little is known about the allergenicity of cross-linked proteins found in bioprocessed dairy products. Objective: The objective of this study was to evaluate the allergenicity of polymerized bovine whey beta-lactoglobulin in symptomatic children diagnosed with IgE-mediated Bos d 5 hypersensitivity. Methods: Side-by-side skin prick tests with native and polymerized bovine whey beta-lactoglobulin were performed in 22 symptomatic children allergic to cow's milk with detectable specific IgE to Bos d 5 by CAP Systems Pharmacia. A matched control group tolerant to cow's milk and undetectable specific IgE to Bos d 5 was established for comparison. Wheal mean diameter was compared between the native and polymerized groups by paired t-tests. Results: The mean difference in wheal mean diameter observed between native versus polymerized bovine whey beta-lactoglobulin in the paired skin prick test of the allergic group was 2.27 mm (p = 0.02; 95% CI 0.38-4.16). Conclusions: The skin prick test showed a significant reduction in the allergenicity of polymerized compared with native bovine whey beta-lactoglobulin in children with IgE-mediated Bos d 5 hypersensitivity.
dc.description25
dc.description1
dc.description30
dc.description33
dc.languageeng
dc.publisherMary Ann Liebert Inc
dc.publisherNew Rochelle
dc.relationPediatric Allergy Immunology and Pulmonology
dc.rightsfechado
dc.sourceWOS
dc.subjectPROTEINS
dc.subjectANTIGENICITY
dc.subjectCYSTEINE
dc.subjectFOODS
dc.titleAllergenicity of Bos d 5 in Children with Cow's Milk Allergy is Reduced by Transglutaminase Polymerization
dc.typeArtículos de revistas


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