The aging lacrimal gland: Changes in structure and function

dc.creatorROCHA, Eduardo M.
dc.creatorALVES, Monica
dc.creatorRIOS, J. David
dc.creatorDARTT, Darlene A.
dc.date2008
dc.date2013-07-26T17:58:21Z
dc.date2016-07-01T15:40:39Z
dc.date2013-07-26T17:58:21Z
dc.date2016-07-01T15:40:39Z
dc.date.accessioned2018-03-29T01:55:58Z
dc.date.available2018-03-29T01:55:58Z
dc.identifierOCULAR SURFACE, v.6, n.4, p.162-174, 2008
dc.identifier1542-0124
dc.identifierhttp://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000259852000006&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
dc.identifierhttp://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000259852000006&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/707
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/707
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308929
dc.descriptionThe afferent nerves of the cornea and conjunctiva, efferent nerves of the lacrimal gland, and the lacrimal gland are a functional unit that works cooperatively to produce the aqueous component of tears. A decrease in the lacrimal gland secretory function can lead to dry eye disease. Because aging is a risk factor for dry eye disease, study of the changes in the function of the lacrimal gland functional unit with age is important for developing treatments to prevent dry eye disease. No one mechanism is known to induce the changes that occur with aging, although multiple different mechanisms have been associated with aging. These fall into two theoretical categories: programmed theories of aging (immunological, genetic, apoptotic, and neuroendocrine) and error theories of aging (protein alteration, somatic mutation, etc). Lacrimal glands undergo structural and functional alteration with increasing age. In mouse models of aging, it has been shown that neural stimulation of protein secretion is an early target of aging, accompanied by an increase in mast cells and lipofuscin accumulation. Hyperglycemia and increased lymphocytic infiltration can contribute to this loss of function at older ages. These findings suggest that an increase in oxidative stress may play a role in the loss of lacrimal gland function with age. For the afferent and efferent neural components of the lacrimal gland functional unit, immune or inflammatory mediated decrease in nerve function could contribute to loss of lacrimal gland secretion with age. More research in this area is critically needed.
dc.description6
dc.description4
dc.description162
dc.description174
dc.languageeng
dc.publisherETHIS COMMUNICATINS, INC
dc.publisherEstados Unidos
dc.relationOcular Surface
dc.rightsfechado
dc.rightsCopyright ETHIS COMMUNICATINS, INC
dc.sourceWOS
dc.subjectaging
dc.subjectdry eye
dc.subjectlacrimal gland
dc.subjectnerve function
dc.subjectprotein secretion
dc.subjectHUMAN TEAR LYSOZYME
dc.subjectEYE WORKSHOP 2007
dc.subjectSTIMULATED PROTEIN SECRETION
dc.subjectSIGNAL-TRANSDUCTION PATHWAYS
dc.subjectPROSTATE EPITHELIAL-CELLS
dc.subjectAGE-RELATED-CHANGES
dc.subjectDRY EYE
dc.subjectSJOGRENS-SYNDROME
dc.subjectOXIDATIVE STRESS
dc.subjectMURINE MODEL
dc.subjectOphthalmology
dc.titleThe aging lacrimal gland: Changes in structure and function
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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