Cardiovascular effects of partial sleep deprivation in healthy volunteers

dc.creatorDettoni, Josilene L.
dc.creatorConsolim-Colombo, Fernanda Marciano
dc.creatorDrager, Luciano F.
dc.creatorRubira, Marcelo C.
dc.creatorCavasin de Souza, Silvia Beatriz P.
dc.creatorIrigoyen, Maria Claudia
dc.creatorMostarda, Cristiano
dc.creatorBorile, Suellen
dc.creatorKrieger, Eduardo M.
dc.creatorMoreno, Heitor, Jr.
dc.creatorLorenzi-Filho, Geraldo
dc.date2012
dc.date2013-09-19T18:06:21Z
dc.date2016-07-01T15:40:38Z
dc.date2013-09-19T18:06:21Z
dc.date2016-07-01T15:40:38Z
dc.date.accessioned2018-03-29T01:55:57Z
dc.date.available2018-03-29T01:55:57Z
dc.identifierJournal of Applied Physiology. Amer Physiological Soc, v.113, n.2, p.232-236, 2012
dc.identifier8750-7587
dc.identifierWOS:000306640700008
dc.identifier10.1152/japplphysiol.01604.2011
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2086
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2086
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308926
dc.descriptionDettoni JL, Consolim-Colombo FM, Drager LF, Rubira MC, de Souza SB, Irigoyen MC, Mostarda C, Borile S, Krieger EM, Moreno H Jr, Lorenzi-Filho G. Cardiovascular effects of partial sleep deprivation in healthy volunteers. J Appl Physiol 113: 232-236, 2012. First published April 26, 2012; doi: 10.1152/japplphysiol.01604.2011.-Sleep deprivation is common in Western societies and is associated with increased cardiovascular morbidity and mortality in epidemiological studies. However, the effects of partial sleep deprivation on the cardiovascular system are poorly understood. In the present study, we evaluated 13 healthy male volunteers (age: 31 +/- 2 yr) monitoring sleep diary and wrist actigraphy during their daily routine for 12 nights. The subjects were randomized and crossover to 5 nights of control sleep (>7 h) or 5 nights of partial sleep deprivation (<5 h), interposed by 2 nights of unrestricted sleep. At the end of control and partial sleep deprivation periods, heart rate variability (HRV), blood pressure variability (BPV), serum norepinephrine, and venous endothelial function (dorsal hand vein technique) were measured at rest in a supine position. The subjects slept 8.0 +/- 0.5 and 4.5 +/- 0.3 h during control and partial sleep deprivation periods, respectively (P < 0.01). Compared with control, sleep deprivation caused significant increase in sympathetic activity as evidenced by increase in percent low-frequency (50 +/- 15 vs. 59 +/- 8) and a decrease in percent high-frequency (50 +/- 10 vs. 41 +/- 8) components of HRV, increase in low-frequency band of BPV, and increase in serum norepinephrine (119 +/- 46 vs. 162 +/- 58 ng/ml), as well as a reduction in maximum endothelial dependent venodilatation (100 +/- 22 vs. 41 +/- 20%; P < 0.05 for all comparisons). In conclusion, 5 nights of partial sleep deprivation is sufficient to cause significant increase in sympathetic activity and venous endothelial dysfunction. These results may help to explain the association between short sleep and increased cardiovascular risk in epidemiological studies.
dc.description113
dc.description2
dc.description232
dc.description236
dc.languageeng
dc.publisherAmer Physiological Soc
dc.publisherBethesda
dc.relationJournal of Applied Physiology
dc.rightsfechado
dc.sourceWOS
dc.subjectsympathetic activity
dc.subjectendothelial dysfunction
dc.subjectAMBULATORY BLOOD-PRESSURE
dc.subjectINSUFFICIENT SLEEP
dc.subjectDURATION
dc.subjectHYPERTENSION
dc.subjectRESPONSES
dc.subjectDISEASE
dc.subjectRISK
dc.titleCardiovascular effects of partial sleep deprivation in healthy volunteers
dc.typeArtículos de revistas


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