Post-menopausal hormone therapy reduces autoantibodies to oxidized apolipoprotein B100

dc.creatorCASTANHO, Vera Sylvia
dc.creatorGIDLUND, Magnus
dc.creatorNAKAMURA, Rui
dc.creatorFARIA, Eliana Cotta de
dc.date2011
dc.date2013-07-26T17:58:51Z
dc.date2016-07-01T15:18:38Z
dc.date2013-07-26T17:58:51Z
dc.date2016-07-01T15:18:38Z
dc.date.accessioned2018-03-29T01:55:44Z
dc.date.available2018-03-29T01:55:44Z
dc.identifierGYNECOLOGICAL ENDOCRINOLOGY, v.27, n.10, p.800-806, 2011
dc.identifier0951-3590
dc.identifier10.3109/09513590.2010.526660
dc.identifierhttp://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000295617600013&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
dc.identifierhttp://dx.doi.org/10.3109/09513590.2010.526660
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/948
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/948
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308872
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThe aim of the study was to verify whether post-menopausal hormone replacement therapy (HRT) modifies autoantibody titers against oxidized low-density lipoprotein (LDL) (anti-LDLoxi), against epitopes of oxidized apolipoprotein B100 and common carotid intima-media thickness (IMT) in these women. Sixty-eight women in pre-menopause (PMW) and 216 in post-menopause (POMW) were recruited; eighty-three had undergone HRT for at least 12 months, where 48 received conjugated estrogens alone (EHRT) and 35 received conjugated estrogen and medroxyprogesterone acetate (CHRT). ELISA was used to determine autoantibodies. Lipoprotein lipase (LPL), hepatic lipase (HL), cholesterol ester transfer protein (CETP) and phospholipid transfer protein (PLTP) activities were assayed by radiometric methods. IMT was measured using Doppler ultrasound. Anti-oxidized LDL and anti-D antibodies increased by 40% (p <= 0.003) and 42% (p <= 0.006), respectively, with menopause. There was a surprising and significant 7% reduction in anti-D2 antibody titers with HRT (p <= 0.050), indicating a positive effect of treatment on the immune response to oxidized LDL. Combined HRT decreased activities of HL and LPL. HRT did not change common carotid IMT, which was increased by 32% as expected after menopause (p <= 0.030). This study describes, for the first time, the protective effect of HRT on decreasing autoantibody titers against oxidized apolipoprotein B in LDL.
dc.description27
dc.description10
dc.description800
dc.description806
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherINFORMA HEALTHCARE
dc.publisherEstados Unidos
dc.relationGynecological Endocrinology
dc.rightsfechado
dc.rightsCopyright INFORMA HEALTHCARE
dc.sourceWOS
dc.subjectPost-menopause hormone replacement therapy
dc.subjectautoantibodies to oxidized LDL
dc.subjectcommon carotid intima media thickness
dc.subjectHDL-cholesterol
dc.subjecthepatic lipase
dc.subjectatherosclerosis
dc.subjectLOW-DENSITY-LIPOPROTEIN
dc.subjectINTIMA-MEDIA THICKNESS
dc.subjectCORONARY-HEART-DISEASE
dc.subjectREPLACEMENT THERAPY
dc.subjectRISK-FACTORS
dc.subjectCAROTID ATHEROSCLEROSIS
dc.subjectHEPATIC LIPASE
dc.subjectARTERY ATHEROSCLEROSIS
dc.subjectINTERMEDIATE DENSITY
dc.subjectTRANSDERMAL ESTROGEN
dc.subjectEndocrinology & Metabolism
dc.subjectObstetrics & Gynecology
dc.titlePost-menopausal hormone therapy reduces autoantibodies to oxidized apolipoprotein B100
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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