Specific matrix metalloproteinase 9 (MMP-9) haplotype affect the circulating MMP-9 levels in women with migraine

dc.creatorMartins-Oliveira, Alisson
dc.creatorGoncalves, Flavia M.
dc.creatorSpeciali, Jose G.
dc.creatorFontana, Vanessa
dc.creatorIzidoro-Toledo, Tatiane C.
dc.creatorBelo, Vanessa A.
dc.creatorDach, Fabiola
dc.creatorTanus-Santos, Jose E.
dc.date2012
dc.date2013-09-19T18:05:53Z
dc.date2016-07-01T15:17:34Z
dc.date2013-09-19T18:05:53Z
dc.date2016-07-01T15:17:34Z
dc.date.accessioned2018-03-29T01:55:42Z
dc.date.available2018-03-29T01:55:42Z
dc.identifierJournal of Neuroimmunology. Elsevier, v.252, n.41306, p.89-94, 2012
dc.identifier0165-5728
dc.identifierWOS:000311132500011
dc.identifier10.1016/j.jneuroim.2012.07.016
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/1802
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/1802
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308859
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionWe investigated whether three relevant polymorphisms (C-1562T, microsatellite - 90(CA)(14-24), and Q279R) in the MMP-9 gene, or MMP-9 haplotypes, are associated with migraine and affect MMP-9 and tissue inhibitor of MMPs (TIMP)-1 levels in patients with migraine. We studied 102 healthy women (controls) and 187 women with migraine (141 without aura - MWA, and 46 with aura - MA). Patients with MWA had higher plasma MMP-9 concentrations than patients with MA. Patients with MA had the highest TIMP-1 and lowest MMP-9/TIMP-1 ratios. The MMP-9 "C L Q" haplotype was associated with higher plasma MMP-9 concentrations in migraine patients. (C) 2012 Elsevier B.V. All rights reserved.
dc.description252
dc.description01/fev
dc.description89
dc.description94
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherElsevier
dc.publisherAmsterdam
dc.relationJournal of Neuroimmunology
dc.rightsfechado
dc.sourceWOS
dc.subjectHaplotype
dc.subjectMatrix metalloproteinase-9
dc.subjectMigraine
dc.subjectPolymorphism
dc.subjectTIMP-1
dc.subjectMATRIX-METALLOPROTEINASE (MMP)-2
dc.subjectBLOOD-BRAIN-BARRIER
dc.subjectCARDIOVASCULAR-DISEASE
dc.subjectHEMORRHAGIC TRANSFORMATION
dc.subjectGENETIC-POLYMORPHISM
dc.subjectHEALTHY-SUBJECTS
dc.subjectOBESE CHILDREN
dc.subjectSTROKE
dc.subjectNEUROBIOLOGY
dc.subjectHYPERTENSION
dc.titleSpecific matrix metalloproteinase 9 (MMP-9) haplotype affect the circulating MMP-9 levels in women with migraine
dc.typeArtículos de revistas


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