Interaction among nitric oxide (NO)-related genes in migraine susceptibility

dc.creatorGoncalves, Flavia M.
dc.creatorLuizon, Marcelo R.
dc.creatorSpeciali, Jose G.
dc.creatorMartins-Oliveira, Alisson
dc.creatorDach, Fabiola
dc.creatorTanus-Santos, Jose E.
dc.date2012
dc.date2013-09-19T18:05:52Z
dc.date2016-07-01T15:17:34Z
dc.date2013-09-19T18:05:52Z
dc.date2016-07-01T15:17:34Z
dc.date.accessioned2018-03-29T01:55:40Z
dc.date.available2018-03-29T01:55:40Z
dc.identifierMolecular and Cellular Biochemistry. Springer, v.370, n.41306, p.183-189, 2012
dc.identifier0300-8177
dc.identifierWOS:000309478600019
dc.identifier10.1007/s11010-012-1409-5
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/1798
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/1798
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308855
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThe pathogenic mechanisms involved in migraine are complex and not completely clarified. Because there is evidence for the involvement of nitric oxide (NO) in migraine pathophysiology, candidate gene approaches focusing on genes affecting the endothelial function have been studied including the genes encoding endothelial NO synthase (eNOS), inducible NO synthase (iNOS), and vascular endothelial growth factor (VEGF). However, investigations on gene-gene interactions are warranted to better elucidate the genetic basis of migraine. This study aimed at characterizing interactions among nine clinically relevant polymorphisms in eNOS (T-786C/rs2070744, the 27 bp VNTR in intron 4, the Glu298Asp/rs1799983, and two additional tagSNPs rs3918226 and rs743506), iNOS (C(-1026)A/rs2779249 and G2087A/rs2297518), and VEGF (C(-2578)A/rs699947 and G(-634)C/rs2010963) in migraine patients and control group. Genotypes were determined by real-time polymerase chain reaction using the Taqman(A (R)) allele discrimination assays or PCR and fragment separation by electrophoresis in 99 healthy women without migraine (control group) and in 150 women with migraine divided into two groups: 107 with migraine without aura and 43 with aura. The multifactor dimensionality reduction method was used to detect and characterize gene-gene interactions. We found a significant interaction between eNOS rs743506 and iNOS 2087G/A polymorphisms in migraine patients compared to control group (P < 0.05), suggesting that this combination affect the susceptibility to migraine. Further studies are needed to determine the molecular mechanisms explaining this interaction.
dc.description370
dc.description01/fev
dc.description183
dc.description189
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherSpringer
dc.publisherDordrecht
dc.relationMolecular and Cellular Biochemistry
dc.rightsfechado
dc.sourceWOS
dc.subjectEndothelial nitric oxide synthase
dc.subjectInducible nitric oxide synthase
dc.subjectEpistasis
dc.subjectMigraine
dc.subjectPolymorphisms
dc.subjectMULTIFACTOR-DIMENSIONALITY REDUCTION
dc.subjectKAPPA-B
dc.subjectPOLYMORPHISMS
dc.subjectHAPLOTYPES
dc.subjectHEADACHE
dc.subjectNEUROBIOLOGY
dc.subjectASSOCIATION
dc.subjectEXPRESSION
dc.subjectEPISTASIS
dc.subjectBLOOD
dc.titleInteraction among nitric oxide (NO)-related genes in migraine susceptibility
dc.typeArtículos de revistas


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