Epistasis among eNOS, MMP-9 and VEGF maternal genotypes in hypertensive disorders of pregnancy

dc.creatorLuizon, Marcelo R.
dc.creatorSandrim, Valeria C.
dc.creatorPalei, Ana C. T.
dc.creatorLacchini, Riccardo
dc.creatorCavalli, Ricardo C.
dc.creatorDuarte, Geraldo
dc.creatorTanus-Santos, Jose E.
dc.date2012
dc.date2013-09-19T18:05:52Z
dc.date2016-07-01T15:17:34Z
dc.date2013-09-19T18:05:52Z
dc.date2016-07-01T15:17:34Z
dc.date.accessioned2018-03-29T01:55:39Z
dc.date.available2018-03-29T01:55:39Z
dc.identifierHypertension Research. Nature Publishing Group, v.35, n.9, p.917-921, 2012
dc.identifier0916-9636
dc.identifierWOS:000308674800007
dc.identifier10.1038/hr.2012.60
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/1797
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/1797
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308854
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionPolymorphisms of the endothelial nitric oxide synthase (eNOS), matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) genes were shown to be associated with hypertensive disorders of pregnancy. However, epistasis is suggested to be an important component of the genetic susceptibility to preeclampsia (PE). The aim of this study was to characterize the interactions among these genes in PE and gestational hypertension (GH). Seven clinically relevant polymorphisms of eNOS (T-786C, rs2070744, a variable number of tandem repeats in intron 4 and Glu298Asp, rs1799983), MMP-9 (C-1562T, rs3918242 and -90(CA)(13-25), rs2234681) and VEGF (C-2578A, rs699947 and G-634C, rs2010963) were genotyped by TaqMan allelic discrimination assays or PCR and fragment separation by electrophoresis in 122 patients with PE, 107 patients with GH and a control group of 102 normotensive pregnant (NP) women. A robust multifactor dimensionality reduction analysis was used to characterize gene-gene interactions. Although no significant genotype combinations were observed for the comparison between the GH and NP groups (P>0.05), the combination of MMP-9-1562CC with VEGF-634GG was more frequent in NP women than in women with PE (P<0.05). Moreover, the combination of MMP-9-1562CC with VEGF-634CC or MMP-9-1562CT with VEGF-634CC or-634GG was more frequent in women with PE than in NP women (P<0.05). These results are obscured when single polymorphisms in these genes are considered and suggest that specific genotype combinations of MMP-9 and VEGF contribute to PE susceptibility. Hypertension Research (2012) 35, 917-921; doi:10.1038/hr.2012.60; published online 10 May 2012
dc.description35
dc.description9
dc.description917
dc.description921
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG-Brazil)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherNature Publishing Group
dc.publisherLondon
dc.relationHypertension Research
dc.rightsfechado
dc.sourceWOS
dc.subjectendothelial nitric oxide synthase gene
dc.subjectepistasis
dc.subjectmatrix metalloproteinase-9 gene
dc.subjectpreeclampsia
dc.subjectvascular endothelial growth factor gene
dc.subjectMULTIFACTOR-DIMENSIONALITY REDUCTION
dc.subjectENDOTHELIAL GROWTH-FACTOR
dc.subjectGENE-GENE INTERACTIONS
dc.subjectGESTATIONAL HYPERTENSION
dc.subjectMATRIX METALLOPROTEINASES
dc.subjectANTIANGIOGENIC FACTORS
dc.subjectHUMAN TROPHOBLASTS
dc.subjectTISSUE INHIBITORS
dc.subjectTYROSINE KINASE-1
dc.subjectPREECLAMPSIA
dc.titleEpistasis among eNOS, MMP-9 and VEGF maternal genotypes in hypertensive disorders of pregnancy
dc.typeArtículos de revistas


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