Assessment of the Expression of IR beta, IRS-1, IRS-2 and IGF-IR beta in a Rat Model of Intrauterine Growth Restriction

dc.creatorBUENO, Marcia Pereira
dc.creatorGUADAGNINI, Dioze
dc.creatorGONCALVES, Frances Lilian Lanhellas
dc.creatorBARINI, Ricardo
dc.creatorSAAD, Mario Jose Abdalla
dc.creatorSCHMIDT, Augusto Frederico
dc.creatorSBRAGIA, Lourenco
dc.date2010
dc.date2013-07-26T17:58:14Z
dc.date2016-07-01T15:11:27Z
dc.date2013-07-26T17:58:14Z
dc.date2016-07-01T15:11:27Z
dc.date.accessioned2018-03-29T01:55:22Z
dc.date.available2018-03-29T01:55:22Z
dc.identifierFETAL DIAGNOSIS AND THERAPY, v.28, n.3, p.145-152, 2010
dc.identifier1015-3837
dc.identifier10.1159/000316932
dc.identifierhttp://dx.doi.org/10.1159/000316932
dc.identifierhttp://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000283549000003&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/665
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/665
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308776
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionObjective: To investigate glomerular development and expression of insulin and insulin-like growth factor receptors in an experimental model of intrauterine growth restriction (IUGR). Material and Methods: We studied three groups of Sprague-Dawley fetuses: IUGR - restricted by ligation of the right uterine artery; C-IUGR - left horn controls, and EC - external controls (non-manipulated). Body and organs were weighed, and glomerular number and volume were analyzed. Expression of IR beta, IRS-1, IRS-2 and IGF-IR beta was analyzed in liver, intestine and kidneys by immunoblotting. Results: Organ/body weight ratios were similar. In IUGR, glomerular number and volume were increased compared to C-IUGR and EC (p < 0.001). In the IUGR liver, increases were found in IGF-IR beta compared to C-IUGR and EC; IR beta compared to EC, and IRS-2 compared to C-IUGR. However, decreases in IR beta were noted in IUGR compared to C-IUGR; IRS-1 compared to C-IUGR and EC, and IRS-2 compared to EC. In IUGR intestine, increases were detected in IR beta, IRS-1 and IGF-IR beta compared to C-IUGR and EC. In IUGR kidneys, increases were observed in IR beta and IGF-IR beta compared to C-IUGR and EC, and IRS-1 compared to EC. Decreased IRS-2 in the intestine and kidney were noticed in IUGR compared to C-IUGR and EC. Conclusion: IUGR fetuses had less glomeruli and alterations in insulin receptors, which may be associated with an increased risk of disease occurrence in adulthood. Copyright (C) 2010 S. Karger AG, Basel
dc.description28
dc.description3
dc.description145
dc.description152
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherKARGER
dc.publisherSuiça
dc.relationFetal Diagnosis and Therapy
dc.rightsfechado
dc.rightsCopyright KARGER
dc.sourceWOS
dc.subjectFetal glomerular development
dc.subjectGlomeruli
dc.subjectInsulin receptor
dc.subjectInsulin-like growth factor receptor
dc.subjectIntrauterine growth restriction
dc.subjectINSULIN-RESISTANCE
dc.subjectFETAL-GROWTH
dc.subjectPOSTNATAL-GROWTH
dc.subjectADULT DISEASE
dc.subjectRETARDATION
dc.subjectRECEPTOR
dc.subjectPROTEINS
dc.subjectHORMONE
dc.subjectGENE
dc.subjectMICE
dc.subjectObstetrics & Gynecology
dc.titleAssessment of the Expression of IR beta, IRS-1, IRS-2 and IGF-IR beta in a Rat Model of Intrauterine Growth Restriction
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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