Atherosclerotic disease in octogenarians: A challenge for science and clinical practice

dc.creatorFreitas, Wladimir M.
dc.creatorCarvalho, Luiz Sergio F.
dc.creatorMoura, Filipe A.
dc.creatorSposito, Andrei C.
dc.date2012
dc.date2013-09-19T18:06:47Z
dc.date2016-07-01T15:09:56Z
dc.date2013-09-19T18:06:47Z
dc.date2016-07-01T15:09:56Z
dc.date.accessioned2018-03-29T01:55:19Z
dc.date.available2018-03-29T01:55:19Z
dc.identifierAtherosclerosis. Elsevier, v.225, n.2, p.281-289, 2012
dc.identifier0021-9150
dc.identifierWOS:000311344700027
dc.identifier10.1016/j.atherosclerosis.2012.06.070
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2408
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2408
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308764
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionBesides the time of exposure to the traditional risk factors, new players take the lead in the modulation of atherogenesis in the very elderly, promoting a step increase in the incidence of cardiovascular events. Accordingly, atherosclerotic plaques become more abundant and portray more unstable features, such as increased inflammatory activity and reduction of smooth muscle cells in the very elderly. This new scenario is composed of new potential modulators of atherogenesis such as cellular senescence, immunosenescence, frailty syndrome, sarcopenia and sirtuins, and changes among the traditional cardiovascular risk factors which gain new attributes and new magnitudes of interaction with atherosclerotic disease. Consistent with this concept, mortality from atherosclerotic disease has shown a decrease in individuals younger than 60 years, but no change in incidence in individuals over the age of 60 years. In this review, we present the most recent and relevant pieces of evidence to the peculiarities of traditional cardiovascular risk factors and new aging-related potential modulators of atherosclerotic disease in very elderly. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
dc.description225
dc.description2
dc.description281
dc.description289
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherElsevier
dc.publisherClare
dc.relationAtherosclerosis
dc.rightsfechado
dc.sourceWOS
dc.subjectAtherogenesis
dc.subjectAging
dc.subjectRisk factors
dc.subjectHIGH-DENSITY-LIPOPROTEIN
dc.subjectENDOTHELIAL PROGENITOR-CELL
dc.subjectII-INDUCED SENESCENCE
dc.subjectSMOOTH-MUSCLE-CELLS
dc.subjectPULSE-WAVE VELOCITY
dc.subjectAGE-RELATED DECLINE
dc.subjectCARDIOVASCULAR-DISEASE
dc.subjectANGIOTENSIN-II
dc.subjectOXIDATIVE STRESS
dc.subjectOLDER-ADULTS
dc.titleAtherosclerotic disease in octogenarians: A challenge for science and clinical practice
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución