The use of vancomycin-loaded poly-l-lactic acid and poly-ethylene oxide microspheres for bone repair: An in vivo study

dc.creatorCoraca-Huber, Debora Cristina
dc.creatorde Rezende Duek, Eliana Aparecida
dc.creatorEtchebehere, Mauricio
dc.creatorMagna, Luis Alberto
dc.creatorIngrid Amstalden, Eliane Maria
dc.date2012
dc.date2013-09-19T18:06:32Z
dc.date2016-07-01T15:08:36Z
dc.date2013-09-19T18:06:32Z
dc.date2016-07-01T15:08:36Z
dc.date.accessioned2018-03-29T01:55:15Z
dc.date.available2018-03-29T01:55:15Z
dc.identifierClinics. Hospital Clinicas, Univ Sao Paulo, v.67, n.7, p.793-798, 2012
dc.identifier1807-5932
dc.identifierWOS:000307723100015
dc.identifier10.6061/clinics/2012(07)15
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2237
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2237
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308754
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionOBJECTIVE: The aim of this study was to investigate bone repair after the implantation of vancomycin-loaded poly-L-lactic acid/poly-ethylene oxide microspheres compared with vancomycin-unloaded poly-L-lactic acid/poly-ethylene oxide microspheres. METHODS: Poly-L-lactic acid/poly-ethylene oxide microspheres were implanted in rat tibiae and evaluated for periods of 2, 4, 8, and 12 days and 4, 8, 16, and 32 weeks. The groups implanted with vancomycin-loaded and vancomycin-unloaded microspheres were compared. Histopathologic (semi-quantitative) and histomorphometric analyses were performed to evaluate the bone formation process. RESULTS: During the first period (second day), fibrin and hemorrhaging areas were observed to be replaced by granulation tissue around the microspheres. Woven bone formation with progressive maturation was observed. All of the histopathological findings, evaluated by a semi-quantitative assay and a quantitative analysis (percentage of bone formation), were similar between the two groups. CONCLUSION: Vancomycin-loaded poly-L-lactic acid/poly-ethylene oxide microspheres are a good bone substitute candidate for bone repair. Local antibiotic therapy using vancomycin-loaded poly-L-lactic acid/poly-ethylene oxide microspheres should be considered after the microbiological evaluation of its efficacy.
dc.description67
dc.description7
dc.description793
dc.description798
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFoundation of Support to Education and Research (FAEP), Sao Paulo, Brazil
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherHospital Clinicas, Univ Sao Paulo
dc.publisherSao Paulo
dc.publisherBrazil
dc.relationClinics
dc.rightsfechado
dc.sourceWOS
dc.subjectPoly-L-lactic acid
dc.subjectPoly-ethylene oxide
dc.subjectVancomycin
dc.subjectBone grafting
dc.subjectIMPLANTS
dc.subjectPOLY(L-LACTIDE)
dc.subjectOSTEOMYELITIS
dc.subjectDEGRADATION
dc.subjectBLENDS
dc.subjectRABBIT
dc.titleThe use of vancomycin-loaded poly-l-lactic acid and poly-ethylene oxide microspheres for bone repair: An in vivo study
dc.typeArtículos de revistas


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