Influence of Focal and Diffuse Extraprostatic Extension and Positive Surgical Margins on Biochemical Progression Following Radical Prostatectomy

dc.creatorBillis, Athanase
dc.creatorMeirelles, Luciana L.
dc.creatorFreitas, Leandro L. L.
dc.creatorMagna, Luis A.
dc.creatorReis, Leonardo O.
dc.creatorFerreira, Ubirajara
dc.date2012
dc.date2013-09-19T18:06:33Z
dc.date2016-07-01T15:08:33Z
dc.date2013-09-19T18:06:33Z
dc.date2016-07-01T15:08:33Z
dc.date.accessioned2018-03-29T01:55:13Z
dc.date.available2018-03-29T01:55:13Z
dc.identifierInternational Braz J Urol. Brazilian Soc Urol, v.38, n.2, p.175-184, 2012
dc.identifier1677-5538
dc.identifierWOS:000306550800008
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2252
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2252
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308744
dc.descriptionPurpose: The amount of extraprostatic extension and positive surgical margin correlates in most studies with biochemical recurrence following radical prostatectomy. We studied the influence of focal and diffuse extraprostatic extension and positive surgical margins on biochemical progression using a simple method for quantification. Materials and Methods: A total of 360 prostates were step-sectioned and totally processed from 175 patients with stage T1c and 185 patients with clinical stage T2 submitted to radical retropubic prostatectomy. Extraprostatic extension was stratified into 2 groups: present up to 1 quadrant and/or section from the bladder neck or apex (Group 1, focal) and in more than 1 quadrant or section (Group 2, diffuse); and, positive surgical margin present up to 2 quadrants and/or sections (Group 1, focal) and in more than 2 quadrants or sections (Group 2, diffuse). The Kaplan-Meier product-limit analysis was used for the time to biochemical recurrence, and an univariate and multivariate Cox stepwise logistic regression model to identify significant predictors. Results: Extraprostatic extension was found in 129/360 (35.8%) patients, 39/129 (30.2%) in Group 1 and 90/129 (69.8%) in Group 2. In univariate analysis but not in multivariate analysis, patients showing diffuse extraprostatic extension (Group 2) had a significant higher risk to develop biochemical recurrence in a shorter time. Positive surgical margin was present in 160/360 (44.4%) patients, 81/160 (50.6%) patients in Group 1 and 79/160 (49.4%) patients in Group 2. Patients with diffuse positive surgical margins (Group 2) had a significant higher risk in both univariate and multivariate analyses. Diffuse positive surgical margin was the strongest predictor on both analyses and an independent predictor on multivariate analysis. Conclusion: Diffuse extraprostatic extension in univariate analysis and positive surgical margins on both univariate and multivariate analyses are significant predictors of shorter time to biochemical progression following radical prostatectomy.
dc.description38
dc.description2
dc.description175
dc.description184
dc.languageeng
dc.publisherBrazilian Soc Urol
dc.publisherRio de Janeiro
dc.publisherBrazil
dc.relationInternational Braz J Urol
dc.rightsfechado
dc.sourceWOS
dc.subjectProstatic neoplasms
dc.subjectextraprostatic extension
dc.subjectpositive surgical margins
dc.subjectradical prostatectomy
dc.subjecttreatment outcome
dc.subjectISUP CONSENSUS CONFERENCE
dc.subjectINTERNATIONAL SOCIETY
dc.subjectANTIGEN RECURRENCE
dc.subjectCANCER
dc.subjectDISEASE
dc.subjectPREDICTOR
dc.subjectINVASION
dc.titleInfluence of Focal and Diffuse Extraprostatic Extension and Positive Surgical Margins on Biochemical Progression Following Radical Prostatectomy
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución