Brasil | Artículos de revistas

Lichen planus and lichenoid drug-induced eruption: a histological and immunohistochemical study

dc.creatorLage, Denise
dc.creatorJuliano, Priscila Bianchini
dc.creatorMetze, Konradin
dc.creatorde Souza, Elemir Macedo
dc.creatorCintra, Maria Leticia
dc.date2012
dc.date2013-09-19T18:06:33Z
dc.date2016-07-01T15:08:33Z
dc.date2013-09-19T18:06:33Z
dc.date2016-07-01T15:08:33Z
dc.date.accessioned2018-03-29T01:55:13Z
dc.date.available2018-03-29T01:55:13Z
dc.identifierInternational Journal of dermatology. Wiley-Blackwell, v.51, n.10, p.1199-1205, 2012
dc.identifier0011-9059
dc.identifierWOS:000309062700008
dc.identifier10.1111/j.1365-4632.2011.05113.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2250
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2250
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308742
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionIntroduction Lichenoid drug eruption (LDE) shares similar features with lichen planus (LP), that could reflect the same pathogenesis. In LP, an autoimmune attack is accepted and cytotoxic T-lymphocytes (CD8+) predominate, especially in late lesions. Apoptosis of keratinocytes may be mediated by CD8+ T and NK cells in two distinct ways: by the release of cytotoxic molecules such as perforin and granzyme B or by the Fas/FasL system. The immunological mechanisms involved in LDE are not yet fully established. Objectives Investigate immunohistological features in LP and LDE to add clues to better understand their pathogenesis. Material and methods Twenty-two patients fulfilled all clinical, laboratory, histopathological, and follow-up features of lichen planus (n = 16) and lichenoid drug eruption (n = 6). Classic histological features favoring LP or LDE were evaluated by two observers. HAM56, MAC387, UCHL-1, OPD4, CD8, Granzyme B, Perforin, and ICAM-1 antibodies were used to decorate the immune infiltrate. Results were analyzed through Pearson correlation, Students t-test, and linear discriminant analysis. Results A higher number of necrotic keratinocytes as well as plasma cells and eosinophils within inflammatory cells were associated with LDE diagnosis. Only in LDE, a correlation was found between the number of T and CD8+ cells and between the number of granzyme B+ cells and apoptotic keratinocytes. Conclusion Our findings suggest a more important role of CD8+ granzyme B-containing cells in LDE group, being its synthesis associated with more intense apoptosis. So, LP and LDE may have a somewhat distinct pathogenesis.
dc.description51
dc.description10
dc.description1199
dc.description1205
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherWiley-Blackwell
dc.publisherHoboken
dc.relationInternational Journal of dermatology
dc.rightsfechado
dc.sourceWOS
dc.subjectGRANZYME-B
dc.subjectT-CELLS
dc.subjectMEDIATED APOPTOSIS
dc.subjectPERFORIN
dc.subjectLYMPHOCYTES
dc.subjectDERMATITIS
dc.subjectDEATH
dc.subjectKERATINOCYTES
dc.subjectPATHOGENESIS
dc.titleLichen planus and lichenoid drug-induced eruption: a histological and immunohistochemical study
dc.typeArtículos de revistas


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