Oxidized low-density lipoproteins and their antibodies: Relationships with the reverse cholesterol transport and carotid atherosclerosis in adults without cardiovascular diseases

dc.creatorFerreira, Paolla F. C.
dc.creatorZago, Vanessa H. S.
dc.creatorD'Alexandri, Fabio L.
dc.creatorPanzoldo, Natalia B.
dc.creatorGidlund, Magnus A.
dc.creatorNakamura, Rui T.
dc.creatorSchreiber, Roberto
dc.creatorParra, Eliane S.
dc.creatorSantiago, Fernanda D.
dc.creatorNakandakare, Edna R.
dc.creatorQuintao, Eder C. R.
dc.creatorde Faria, Eliana C.
dc.date2012
dc.date2013-09-19T18:06:33Z
dc.date2016-07-01T15:08:32Z
dc.date2013-09-19T18:06:33Z
dc.date2016-07-01T15:08:32Z
dc.date.accessioned2018-03-29T01:55:12Z
dc.date.available2018-03-29T01:55:12Z
dc.identifierClinica Chimica Acta. Elsevier, v.413, n.19-20, p.1472-1478, 2012
dc.identifier0009-8981
dc.identifierWOS:000307924000009
dc.identifier10.1016/j.cca.2012.05.020
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2245
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2245
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308737
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionBackground: Metabolic predictors and the atherogenicity of oxidized LDL (oxLDL) and the specific antibodies against oxLDL (oxLDL Ab) are unclear and controversial. Methods: In 107 adults without atherosclerotic manifestations, we measured oxLDL and oxLDL Ab, and also the activities of CETP. PLTP, lipases and the carotid intima-media thickness (cIMT). Comparisons were performed for the studied parameters between the lowest and the highest tertile of oxLDL and oxLDL Ab, and the relationships between studied variables were evaluated. Results: Subjects with higher oxLDL Ab present reduced hepatic lipase activity and borderline increased cIMT. In the highest oxLDL tertile, besides the higher levels of total cholesterol, LDL-C and apoB100, we found reduced CETP activity and higher cIMT. A significant correlation between oxLDL Ab and cIMT, independent of oxLDL, and a borderline correlation between oxLDL and cIMT independent of oxLDL Ab were found. In the multivariate analysis, apoAl was a significant predictor of oxLDL Ab, in contrast to regulation of oxLDL by apoB100, PLTP and inverse of CETP. Conclusions: In adults without atherosclerotic disease, the metabolic regulation and carotid atherosclerosis of oxLDLAb and oxLDL groups, characterized a dual trait in oxLDL Ab, as a contributor to carotid atherosclerosis, much less so than oxidized LDL, and with a modest atheroprotective role. (C) 2012 Elsevier B.V. All rights reserved.
dc.description413
dc.description19-20
dc.description1472
dc.description1478
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherElsevier
dc.publisherAmsterdam
dc.relationClinica Chimica Acta
dc.rightsfechado
dc.sourceWOS
dc.subjectOxidized LDL
dc.subjectAntibodies against oxidized LDL
dc.subjectCarotid intima-media thickness
dc.subjectCholesteryl ester transfer protein
dc.subjectPhospholipid transfer protein
dc.subjectHepatic lipase
dc.subjectINTIMA-MEDIA THICKNESS
dc.subjectESTER TRANSFER PROTEIN
dc.subjectCORONARY HEART-DISEASE
dc.subjectAPOLIPOPROTEIN-A-I
dc.subjectIMMUNE-COMPLEXES
dc.subjectHEALTHY POPULATION
dc.subjectHDL-CHOLESTEROL
dc.subjectLDL
dc.subjectOXLDL
dc.subjectRISK
dc.titleOxidized low-density lipoproteins and their antibodies: Relationships with the reverse cholesterol transport and carotid atherosclerosis in adults without cardiovascular diseases
dc.typeArtículos de revistas


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