Association of HPV infection and Chlamydia trachomatis seropositivity in cases of cervical neoplasia in Midwest Brazil

dc.creatorda Silva Barros, Narriman Kennia
dc.creatorCosta, Maria Cecilia
dc.creatorFigueiredo Alves, Rosane Ribeiro
dc.creatorVilla, Luisa Lina
dc.creatorMauricette Derchain, Sophie Francoise
dc.creatorZeferino, Luiz Carlos
dc.creatordos Santos Carneiro, Megmar Aparecida
dc.creatorRabelo-Santos, Silvia Helena
dc.date2012
dc.date2013-09-19T18:06:31Z
dc.date2016-07-01T15:06:40Z
dc.date2013-09-19T18:06:31Z
dc.date2016-07-01T15:06:40Z
dc.date.accessioned2018-03-29T01:55:09Z
dc.date.available2018-03-29T01:55:09Z
dc.identifierJournal of Medical Virology. Wiley-Blackwell, v.84, n.7, p.1143-1150, 2012
dc.identifier0146-6615
dc.identifierWOS:000303994200021
dc.identifier10.1002/jmv.23312
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2222
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2222
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308726
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionHigh-risk human papillomavirus (HPV) is considered the main etiological agent for cervical neoplasia. However, the presence of a single type HPV infection alone is unlikely to be sufficient to cause cervical cancer. There is epidemiologic evidence suggesting that HPV and Chlamydia trachomatis play a central role in the etiology of cervical intraepithelial neoplasia and subsequent cervical cancer. To evaluate the HPV prevalence and the seropositivity for C. trachomatis in women referred to the colposcopy clinic due to an abnormal cervical smear and to examine the effect of this association on the severity of cervical neoplasia. Following enrollment, 131 patients underwent colposcopy and biopsies when necessary. HPV DNA was detected by the polymerase chain reaction (PCR) and genotyping was performed by reverse line-blot hybridization assay. C. trachomatis seropositivity was tested by ELISA for the detection of IgG antibodies. The prevalence of HPV infection was 86.3%. Seropositivity for C. trachomatis was 26%. Thirty-one women (27.4%) were positive for C. trachomatis antibodies and HPV-DNA. The most prevalent HPV type in C. trachomatis-seropositive women were HPV 16 (51.6%) and this HPV type was present mainly in neoplasia cases. Positivity for HPV, particularly HPV types 16 and 18, and C. trachomatis seropositivity was significantly associated with a diagnosis of high grade neoplasia. Borderline significance was observed after adjustment for HPV. C. trachomatis seropositivity is associated with high grade neoplasia in women infected with HPV, mainly when the types 16 and 18 were involved. J. Med. Virol. 84: 11431150, 2012. (C) 2012 Wiley Periodicals, Inc.
dc.description84
dc.description7
dc.description1143
dc.description1150
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherWiley-Blackwell
dc.publisherMalden
dc.relationJournal of Medical Virology
dc.rightsfechado
dc.sourceWOS
dc.subjectcervical intraepithelial neoplasia
dc.subjectcervical cancer
dc.subjectcervical smear
dc.subjectPCR
dc.subjectserology
dc.subjectSQUAMOUS-CELL CARCINOMA
dc.subjectHUMAN-PAPILLOMAVIRUS
dc.subjectINTRAEPITHELIAL NEOPLASIA
dc.subjectRISK
dc.subjectCANCER
dc.subjectWOMEN
dc.subjectANTIBODIES
dc.subjectCOFACTOR
dc.subjectSAMPLES
dc.subjectSINGLE
dc.titleAssociation of HPV infection and Chlamydia trachomatis seropositivity in cases of cervical neoplasia in Midwest Brazil
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución