Longitudinal outcomes of high-risk human papillomavirus (HPV) infections as competing-risks events following cervical HPV test at baseline visit in the *NIS-LAMS** cohort

dc.creatorSyrjanen, K.
dc.creatorShabalova, I.
dc.creatorSarian, L.
dc.creatorNaud, P.
dc.creatorLongatto-Filho, A.
dc.creatorDerchain, S.
dc.creatorKozachenko, V.
dc.creatorZakharchenko, S.
dc.creatorRoteli-Martins, C.
dc.creatorNerovjna, R.
dc.creatorKljukina, L.
dc.creatorTatti, S.
dc.creatorBranovskaja, M.
dc.creatorBranca, M.
dc.creatorGrunjberga, V.
dc.creatorErzen, M.
dc.creatorJuschenko, A.
dc.creatorSerpa Hammes, L.
dc.creatorPodistov, J.
dc.creatorCosta, S.
dc.creatorSyrjanen, S.
dc.date2012
dc.date2013-09-19T18:06:32Z
dc.date2016-07-01T15:06:36Z
dc.date2013-09-19T18:06:32Z
dc.date2016-07-01T15:06:36Z
dc.date.accessioned2018-03-29T01:55:09Z
dc.date.available2018-03-29T01:55:09Z
dc.identifierEuropean Journal of Gynaecological Oncology. I R O G Canada, Inc, v.33, n.4, p.341-352, 2012
dc.identifier0392-2936
dc.identifierWOS:000307158700001
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2226
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2226
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308724
dc.descriptionBackground: The complex natural history of human papillomavirus (HPV) infections following a single HPV test can be modeled as competing-risks events (i.e., no-, transient- or persistent infection) in a longitudinal setting. The covariates associated with these compet ng events have not been previously assessed using competing-risks regression models. Objectives: To gain further insights in the outcomes of cervical HPV infections, we used univariate- and multivariate competing-risks regression models to assess the covariaies associated with these competing events. Study Design and Methods: Covariates associated with three competing outcomes (no-, transient- or persistent HR-HPV infection) were analysed in a sub-cohort of 1,865 women prospectively followed-up in the NIS (n = 3,187) and LAMS Study (n = 12,114). Results: In multivariate competing-risks models (with two other outcomes as competing events), permanently HR-HPV negative outcome was significantly predicted only by the clearance of ASCUS+Pap during FU, while three independent covariates predicted transient HR-HPV infections: i) number of recent (< 12 months) sexual partners (risk increased), ii) previous Pap screening history (protective), and history of previous CIN (increased risk). The two most powerful predictors of persistent HR-HPV infections were persistent ASCUS+Pap (risk increased), and previous Pap screening history (protective). In pair-wise comparisons, number of recent sexual partners and previous CIN history increase the probability of transient HR-HPV infection against the HR-HPV negative competing event, while previous Pap screening history is protective. Persistent ASCUS+Pap during FU and no previous Pap screening history are significantly associated with the persistent HR-HPV outcome (compared both with i) always negative, and ii) transient events), whereas multiparity is protective. Conclusions: Different covariates are associated with the three main outcomes of cervical HPV infections. The most significant covariates of each competing events are probably distinct enough to enable constructing of a risk-profile for each main outcome.
dc.description33
dc.description4
dc.description341
dc.description352
dc.descriptionINCO-Copernicus of the European Commission [ERB IC15-CT98-0321]
dc.descriptionEuropean Commission [ICA4-CT-2001-10013]
dc.languageeng
dc.publisherI R O G Canada, Inc
dc.publisherMontreal
dc.relationEuropean Journal of Gynaecological Oncology
dc.rightsfechado
dc.sourceWOS
dc.subjectHPV
dc.subjectNatural history
dc.subjectOutcomes
dc.subjectCompeting events
dc.subjectCompeting-risks regression model
dc.subjectTransient infection
dc.subjectPersistent infection
dc.subjectProspective follow-up
dc.subjectNIS Cohort
dc.subjectLAMS Study
dc.subjectFORMER SOVIET-UNION
dc.subjectFINNISH FAMILY HPV
dc.subjectLOW-RESOURCE SETTINGS
dc.subjectSURROGATE END-POINTS
dc.subjectINDEPENDENT STATES
dc.subjectNATURAL-HISTORY
dc.subjectPAP-SMEAR
dc.subjectLATIN-AMERICA
dc.subjectWOMEN
dc.subjectPERSISTENCE
dc.titleLongitudinal outcomes of high-risk human papillomavirus (HPV) infections as competing-risks events following cervical HPV test at baseline visit in the *NIS-LAMS** cohort
dc.typeArtículos de revistas


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