Performance characteristics of Pap test, VIA, VILI, HR-HPV testing, cervicography, and colposcopy in diagnosis of significant cervical pathology

dc.creatorLongatto-Filho, Adhemar
dc.creatorNaud, Paulo
dc.creatorDerchain, Sophie F. M.
dc.creatorRoteli-Martins, Cecilia
dc.creatorTatti, Silvio
dc.creatorHammes, Luciano Serpa
dc.creatorSarian, Luis Otavio
dc.creatorErzen, Mojca
dc.creatorBranca, Margherita
dc.creatorde Matos, Jean Carlos
dc.creatorGontijo, Renata
dc.creatorMaeda, Marina Y. S.
dc.creatorLima, Temistocles
dc.creatorCosta, Silvano
dc.creatorSyrjanen, Stina
dc.creatorSyrjanen, Kari
dc.date2012
dc.date2013-09-19T18:06:31Z
dc.date2016-07-01T15:06:35Z
dc.date2013-09-19T18:06:31Z
dc.date2016-07-01T15:06:35Z
dc.date.accessioned2018-03-29T01:55:08Z
dc.date.available2018-03-29T01:55:08Z
dc.identifierVirchows Archiv. Springer, v.460, n.6, p.577-585, 2012
dc.identifier0945-6317
dc.identifierWOS:000305134900004
dc.identifier10.1007/s00428-012-1242-y
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2223
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2223
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308721
dc.descriptionWe sought to evaluate the performance of diagnostic tools to establish an affordable setting for early detection of cervical cancer in developing countries. We compared the performance of different screening tests and their feasibility in a cohort of over 12,000 women: conventional Pap smear, liquid-based cytology, visual inspection with acetic acid (VIA), visual inspection with Iodine solution (VILI), cervicography, screening colposcopy, and high-risk human papillomavirus (HPV) testing (HR-HPV) collected by physician and by self-sampling. HR-HPV assay collected by the physician has the highest sensitivity (80 %), but high unnecessary referrals to colposcopy (15.1 %). HR-HPV test in self-sampling had a markedly lower (57.1 %) sensitivity. VIA, VILI, and cervicography had a poor sensitivity (47.4, 55, and 28.6 %, respectively). Colposcopy presented with sensitivity of 100 % in detecting CIN2+, but the lowest specificity (66.9 %). Co-testing with VIA and VILI Pap test increased the sensitivity of stand-alone Pap test from 71.6 to 87.1 % and 71.6 to 95 %, respectively, but with high number of unnecessary colposcopies. Co-testing with HR-HPV importantly increased the sensitivity of Pap test (to 86 %), but with high number of unnecessary colposcopies (17.5 %). Molecular tests adjunct to Pap test seems a realistic option to improve the detection of high-grade lesions in population-based screening programs.
dc.description460
dc.description6
dc.description577
dc.description585
dc.descriptionEuropean Commission, INCO-DEV [ICA4-CT-2001-10013]
dc.languageeng
dc.publisherSpringer
dc.publisherNew York
dc.relationVirchows Archiv
dc.rightsfechado
dc.sourceWOS
dc.subjectCancer prevention
dc.subjectPap test
dc.subjectHybrid capture
dc.subjectColposcopy
dc.subjectScreening program
dc.subjectLIQUID-BASED CYTOLOGY
dc.subjectRANDOMIZED CONTROLLED-TRIAL
dc.subjectVISUAL INSPECTION METHODS
dc.subjectOPTIONAL SCREENING TOOLS
dc.subjectLUGOLS IODINE VILI
dc.subjectACETIC-ACID
dc.subjectLATIN-AMERICA
dc.subjectINTRAEPITHELIAL NEOPLASIA
dc.subjectTEST ACCURACY
dc.subjectRURAL INDIA
dc.titlePerformance characteristics of Pap test, VIA, VILI, HR-HPV testing, cervicography, and colposcopy in diagnosis of significant cervical pathology
dc.typeArtículos de revistas


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