Periacinar Retraction Clefting in Nonneoplastic and Neoplastic Prostatic Glands: Artifact or Molecular Involvement

dc.creatorFavaro, Wagner Jose
dc.creatorHetzl, Amanda Cia
dc.creatorReis, Leonardo Oliveira
dc.creatorFerreira, Ubirajara
dc.creatorBillis, Athanase
dc.creatorCagnon, Valeria Helena A.
dc.date2012
dc.date2013-09-19T18:06:29Z
dc.date2016-07-01T14:37:09Z
dc.date2013-09-19T18:06:29Z
dc.date2016-07-01T14:37:09Z
dc.date.accessioned2018-03-29T01:54:31Z
dc.date.available2018-03-29T01:54:31Z
dc.identifierPathology & Oncology Research. Springer, v.18, n.2, p.285-292, 2012
dc.identifier1219-4956
dc.identifierWOS:000303538200021
dc.identifier10.1007/s12253-011-9440-5
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2196
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2196
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308568
dc.descriptionA space between neoplastic acini and prostatic stroma is not rare and studies have interpreted this as an artifact, considering the absence of endothelial cells indicating vascular invasion. Thus, the aims of this work were to characterize and correlate the occurrence and extent of retraction clefting with the reactivities of alpha and beta dystroglycan (alpha DG, beta DG), laminin, matrix metalloproteinase 2 (MMP-2), p63, insulin-like growth factor 1(IGF-1), vimentin, and fibroblast growth factor 2 (FGF-2). The study was based on nonneoplastic and neoplastic prostatic tissues obtained from necropsies and retropubic radical prostatectomies. The results showed that periacinar retraction clefting was significantly more frequent in prostatic carcinoma samples than in normal prostatic acini. Most of the neoplastic acini (72.0%) showed retraction clefting of more than 50% of circumference, which were significantly more frequent in Gleason score 7 and 6. Decreased collagen and reticular and elastic fibers were verified in the stroma around neoplastic acini. Weak and discontinuous alpha DG, beta DG, and laminin immunoreactivities and intensified MMP-2, vimentin, IGF-1 and FGF-2 immunoreactivities were verified in the neoplastic acini; p63 immunoreactivity was negative in all carcinomas. Thus, these findings showed that the lack of epithelial basal cells, DGs, and laminin and increased MMP-2, IGF-1, and FGF-7 could be considered important pathways in periacinar retraction occurrence. This study demonstrated the origin of and the biological mechanisms responsible for periacinar retraction clefting in prostatic carcinoma.
dc.description18
dc.description2
dc.description285
dc.description292
dc.languageeng
dc.publisherSpringer
dc.publisherDordrecht
dc.relationPathology & Oncology Research
dc.rightsfechado
dc.sourceWOS
dc.subjectProstatic cancer
dc.subjectHistological criteria
dc.subjectRetraction clefting
dc.subjectDystroglycans
dc.subjectMatrix metalloproteinases
dc.subjectInsulin-like growth factor
dc.subjectFibroblast growth factor
dc.subjectVimentin
dc.subjectLaminin
dc.subjectp63
dc.subjectNEEDLE CORE BIOPSIES
dc.subjectTUMOR PROGRESSION
dc.subjectGROWTH-FACTORS
dc.subjectDYSTROGLYCAN EXPRESSION
dc.subjectSTROMAL REACTION
dc.subjectCANCER CELLS
dc.subjectADENOCARCINOMA
dc.subjectRECEPTORS
dc.subjectMATRIX
dc.subjectCARCINOMA
dc.titlePeriacinar Retraction Clefting in Nonneoplastic and Neoplastic Prostatic Glands: Artifact or Molecular Involvement
dc.typeArtículos de revistas


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