Artículos de revistas
Differential usage of NF-kappa B activating signals by IL-1 beta and TNF-alpha in pancreatic beta cells
Registro en:
Febs Letters. Elsevier, v.586, n.7, p.984-989, 2012
0014-5793
WOS:000302268400007
10.1016/j.febslet.2012.02.021
Autor
Ortis, F.
Miani, M.
Colli, M. L.
Cunha, D. A.
Gurzov, E. N.
Allagnat, F.
Chariot, A.
Eizirik, D. L.
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) The cytokines interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha induce beta-cell death in type 1 diabetes via NF-kappa B activation. IL-1 beta induces a more marked NF-kappa B activation than TNF-alpha, with higher expression of genes involved in beta-cell dysfunction and death. We show here a differential usage of the IKK complex by IL-1 beta and TNF-alpha in beta-cells. While TNF-alpha uses IKK complexes containing both IKK alpha and IKK beta, IL-1 beta induces complexes with IKKa only; this effect is achieved by induction of IKK beta degradation via the proteasome. Both IKK gamma and activation of the TRAF6-TAK1-JNK pathway are involved in IL-1 beta-induced IKK beta degradation. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. 586 7 984 989 Fonds National de la Recherche Scientifique (FNRS) Belgium Communaute Francaise de Belgique - Actions de Recherche Concertees (ARC) European Union Dutch Diabetes Research Foundation [2008.40.001] Belgium Program on Interuniversity Poles of Attraction [IUAP P6/40] Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)