Leishmanicidal activity of fractions rich in aporphine alkaloids from Amazonian Unonopsis species

dc.creatorda Silva, Felipe M. A.
dc.creatorKoolen, Hector H. F.
dc.creatorde Lima, Janaina P. S.
dc.creatorSantos, Delvania M. F.
dc.creatorJardim, Izaltina Silva
dc.creatorde Souza, Afonso D. L.
dc.creatorBelem Pinheiro, Maria Lucia
dc.date2012
dc.date2013-09-19T18:06:16Z
dc.date2016-07-01T12:55:28Z
dc.date2013-09-19T18:06:16Z
dc.date2016-07-01T12:55:28Z
dc.date.accessioned2018-03-29T01:53:52Z
dc.date.available2018-03-29T01:53:52Z
dc.identifierRevista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy. Soc Brasileira Farmacognosia, v.22, n.6, p.1368-1371, 2012
dc.identifier0102-695X
dc.identifierWOS:000312200500024
dc.identifier10.1590/S0102-695X2012005000103
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2024
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2024
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308505
dc.descriptionIn vitro evaluation of alkaloidal fractions of twigs, barks and leaves from two Unonopsis species, Unonopsis guatterioides R.E. Fr. and Unonopsis duckei R.E. Fr., Annonaceae, against promastigote forms of Leishmania amazonensis revealed these species as sources of substances with promising leishmanicidal potential. All alkaloidal fractions from twigs, barks and leaves of U. guatterioides were classified as highly active, with IC50 1.07, 1.90, and 2.79 mg/mL, respectively. Only the alkaloidal fraction from the twigs of U. duckei was classified as inactive.
dc.description22
dc.description6
dc.description1368
dc.description1371
dc.languageeng
dc.publisherSoc Brasileira Farmacognosia
dc.publisherJoao Pessoa
dc.publisherBrazil
dc.relationRevista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy
dc.rightsaberto
dc.sourceWOS
dc.subjectaporphine alkaloids
dc.subjectleishmanicidal activity
dc.subjectUnonopsis duckei
dc.subjectUnonopsis guatterioides
dc.subjectNATURAL-PRODUCTS
dc.subjectANTILEISHMANIAL ACTIVITY
dc.subjectANTIPROTOZOAL ACTIVITY
dc.subjectCYTOTOXIC ACTIVITIES
dc.subjectANNONACEAE
dc.subjectPLANTS
dc.titleLeishmanicidal activity of fractions rich in aporphine alkaloids from Amazonian Unonopsis species
dc.typeArtículos de revistas


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