Artículos de revistas
Quimioterapia da doença de Chagas: estado da arte e perspectivas no desenvolvimento de novos fármacos
Chemotherapy of Chagas' disease: state of the art and perspectives for the development of new drugs
Registro en:
Química Nova, v.32, n.9, p.2444-2457, 2009
0100-4042
10.1590/S0100-40422009000900038
Autor
DIAS, Luiz C.
DESSOY, Marco A.
SILVA, Jean Jerley N.
THIEMANN, Otavio H.
OLIVA, Glaucius
ANDRICOPULO, Adriano D.
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Neglected diseases are a major global cause of illness, long-term disability and death. Chagas' disease is a parasitic infection widely distributed throughout Latin America, with devastating consequences in terms of human morbidity and mortality. The existing drug therapy suffers from a combination of drawbacks including poor efficacy, resistance and serious side effects. In 2009, we celebrate the 100th anniversary of the discovery of Chagas' disease, facing the challenges of developing new, safe and effective drugs for the treatment of this disease. This brief review attempts to highlight the state of the art, limitations and perspectives of Chagas' disease drug development. 32 9 2444 2457 WHO World Health Organization - Organização Mundial de Saúde Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) CNPq_Brasil FAPESP_Brasil WHO