Chitosan-solid lipid nanoparticles as carriers for topical delivery of tretinoin

dc.creatorRidolfi, Daniela M.
dc.creatorMarcato, Priscyla D.
dc.creatorJusto, Giselle Z.
dc.creatorCordi, Livia
dc.creatorMachado, Daisy
dc.creatorDuran, Nelson
dc.date2012
dc.date2013-09-19T18:06:11Z
dc.date2016-07-01T12:54:31Z
dc.date2013-09-19T18:06:11Z
dc.date2016-07-01T12:54:31Z
dc.date.accessioned2018-03-29T01:53:50Z
dc.date.available2018-03-29T01:53:50Z
dc.identifierColloids and Surfaces B-Biointerfaces. Elsevier, v.93, p.36-40, 2012
dc.identifier0927-7765
dc.identifierWOS:000302431900006
dc.identifier10.1016/j.colsurfb.2011.11.051
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/1958
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/1958
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308496
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionTretinoin (TRE) or all-trans retinoic acid is employed in the topical treatment of various skin diseases including acne and psoriasis. However, its use is strongly limited by side effects and high chemical instability. TRE encapsulation in nanostructured systems reduces these problems. Chitosan is a biopolymer that exhibits a number of interesting properties such as bioadhesion and antibacterial activity. The aim of this work was to prepare and characterize solid lipid nanoparticles (SLN) containing TRE, with and without addition of chitosan, to assess their in vitro cytotoxicity in keratinocytes and to evaluate their antibacterial activity against bacteria related to acne. SLN without (SLN-TRE) and with (SLN-chitosan-TRE) chitosan were prepared by hot high pressure homogenization. The hydrodynamic mean diameter and zeta potential were 162.7 +/- 1.4 nm and -31.9 +/- 2.0 mV for SLN-TRE, and 284.8 +/- 15.0 nm and 55.9 +/- 3.1 mV for SLN-chitosan-TRE. The SLN-chitosan-TRE exhibited high encapsulation efficiency, high physical stability in the tested period (one year), were not cytotoxic to keratinocytes and showed high antibacterial activity against P. acnes and S. aureus. Therefore chitosan-SLN can be good candidates to encapsulate TRE and to increase its therapeutic efficacy in the topical treatment of acne. (C) 2011 Elsevier B.V. All rights reserved.
dc.description93
dc.description36
dc.description40
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionINCT Functional Complex Materials INOMAT (MCT/CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherElsevier
dc.publisherAmsterdam
dc.relationColloids and Surfaces B-Biointerfaces
dc.rightsfechado
dc.sourceWOS
dc.subjectAll-trans retinoic acid
dc.subjectAntibacterial activity
dc.subjectChitosan
dc.subjectCytotoxicity
dc.subjectSolid lipid nanoparticles
dc.subjectTretinoin
dc.subjectANTIBACTERIAL ACTIVITY
dc.subjectDRUG-DELIVERY
dc.subjectIN-VITRO
dc.subjectSLN
dc.subjectRETINOIDS
dc.subjectSKIN
dc.subjectPHOTOSTABILITY
dc.subjectMANAGEMENT
dc.subjectACNE
dc.titleChitosan-solid lipid nanoparticles as carriers for topical delivery of tretinoin
dc.typeArtículos de revistas


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