Nanoassisted Laser Desorption-Ionization-MS Imaging of Tumors

dc.creatorTata, Alessandra
dc.creatorFernandes, Anna Maria A. P.
dc.creatorSantos, Vanessa G.
dc.creatorAlberici, Rosana M.
dc.creatorAraldi, Dioneia
dc.creatorParada, Carlos A.
dc.creatorBraguini, Wellington
dc.creatorVeronez, Luciana
dc.creatorBisson, Gabriela Silva
dc.creatorReis, Felippe H. Z.
dc.creatorAlberici, Luciane C.
dc.creatorEberlin, Marcos N.
dc.date2012
dc.date2013-09-19T18:06:42Z
dc.date2016-07-01T12:52:02Z
dc.date2013-09-19T18:06:42Z
dc.date2016-07-01T12:52:02Z
dc.date.accessioned2018-03-29T01:53:38Z
dc.date.available2018-03-29T01:53:38Z
dc.identifierAnalytical Chemistry. Amer Chemical Soc, v.84, n.15, p.6341-6345, 2012
dc.identifier0003-2700
dc.identifierWOS:000307159200014
dc.identifier10.1021/ac301202q
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2369
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2369
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308448
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThe ability of nanoassisted laser desorption-ionization mass spectrometry (NALDI-MS) imaging to provide selective chemical monitoring with proper spatial distribution of lipid profiles from tumor tissues after plate imprinting has been tested. NALDI-MS imaging identified and mapped several potential lipid biomarkers in a murine model of melanoma tumor (inoculation of B16/F10 cells). It also confirmed that the in vivo treatment of tumor bearing mice with synthetic supplement containing phosphoethanolamine (PHO-S) promoted an accentuated decrease in relative abundance of the tumor biomarkers. NALDI-MS imaging is a matrix-free LDI protocol based on the selective imprinting of lipids in the NALDI plate followed by the removal of the tissue. It therefore provides good quality and selective chemical images with preservation of spatial distribution and less interference from tissue material. The test case described herein illustrates the potential of chemically selective NALDI-MS imaging for biomarker discovery.
dc.description84
dc.description15
dc.description6341
dc.description6345
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherAmer Chemical Soc
dc.publisherWashington
dc.relationAnalytical Chemistry
dc.rightsfechado
dc.sourceWOS
dc.subjectMALDI-TOF-MS
dc.subjectMASS-SPECTROMETRY
dc.subjectELECTROSPRAY-IONIZATION
dc.subjectCARBON NANOTUBES
dc.subjectPOROUS SILICON
dc.subjectDESORPTION/IONIZATION
dc.subjectTISSUES
dc.subjectMATRIX
dc.subjectCANCER
dc.subjectBRAIN
dc.titleNanoassisted Laser Desorption-Ionization-MS Imaging of Tumors
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución