Substantivity of chlorhexidine to human dentin

dc.creatorCARRILHO, Marcela R.
dc.creatorCARVALHO, Ricardo M.
dc.creatorSOUSA, Ethan N.
dc.creatorNICOLAU, Jose
dc.creatorBRESCHI, Lorenzo
dc.creatorMAZZONI, Annalisa
dc.creatorTJADERHANE, Leo
dc.creatorTAY, Franklin R.
dc.creatorAGEE, Kelli
dc.creatorPASHLEY, David H.
dc.date2010
dc.date2013-07-26T17:58:32Z
dc.date2016-06-30T20:33:03Z
dc.date2013-07-26T17:58:32Z
dc.date2016-06-30T20:33:03Z
dc.date.accessioned2018-03-29T01:53:32Z
dc.date.available2018-03-29T01:53:32Z
dc.identifierDENTAL MATERIALS, v.26, n.8, p.779-785, 2010
dc.identifier0109-5641
dc.identifier10.1016/j.dental.2010.04.002
dc.identifierhttp://dx.doi.org/10.1016/j.dental.2010.04.002
dc.identifierhttp://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000279068500008&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/775
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/775
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308424
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionObjectives. To better comprehend the role of CHX in the preservation of resin-dentin bonds, this study investigated the substantivity of CHX to human dentin. Material and methods. Dentin disks (n = 45) were obtained from the mid-coronal portion of human third molars. One-third of dentin disks were kept mineralized (MD), while the other two-thirds had one of the surfaces partially demineralized with 37% phosphoric acid for 15 s (PDD) or they were totally demineralized with 10% phosphoric acid (TDD). Disks of hydroxyapatite (HA) were also prepared. Specimens were treated with: (1) 10 mu L of distilled water (controls), (2) 10 mu L of 0.2% chlorhexidine diacetate (0.2% CHX) or (3) 10 mu L of 2% chlorhexidine diacetate (2% CHX). Then, they were incubated in 1 mL of PBS (pH 7.4, 37 degrees C). Substantivity was evaluated as a function of the CHX-applied dose after: 0.5 h, 1 h, 3 h, 6 h, 24 h, 168 h (1 week), 672 h (4 weeks) and 1344 h (8 weeks) of incubation. CHX concentration in eluates was spectrophotometrically analyzed at 260 nm. Results. Significant amounts of CHX remained retained in dentin substrates (MD, PPD or TDD), independent on the CHX-applied dose or time of incubation (p < 0.05). High amounts of retained CHX onto HA were observed only for specimens treated with the highest concentration of CHX (2%) (p < 0.05). Conclusion. The outstanding substantivity of CHX to dentin and its reported effect on the inhibition of dentinal proteases may explain why CHX can prolong the durability of resin-dentin bonds. (C) 2010 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.
dc.description26
dc.description8
dc.description779
dc.description785
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionNIDCR, USA[R01-DE-015306-6]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherELSEVIER SCI LTD
dc.publisherInglaterra
dc.relationDental Materials
dc.rightsfechado
dc.rightsCopyright ELSEVIER SCI LTD
dc.sourceWOS
dc.subjectDentin
dc.subjectChlorhexidine
dc.subjectBinding
dc.subjectSubstantivity
dc.subjectLAYERS IN-VIVO
dc.subjectHYBRID LAYERS
dc.subjectANTIMICROBIAL AGENTS
dc.subjectRELEASE
dc.subjectHYDROXYAPATITE
dc.subjectADSORPTION
dc.subjectCOLLAGEN
dc.subjectVITRO
dc.subjectMETHACRYLATE
dc.subjectDEGRADATION
dc.subjectDentistry, Oral Surgery & Medicine
dc.subjectMaterials Science, Biomaterials
dc.titleSubstantivity of chlorhexidine to human dentin
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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