Budesonide-hydroxypropyl-beta-cyclodextrin Inclusion Complex In Binary Poloxamer 407/403 System For Ulcerative Colitis Treatment: A Physico-chemical Study From Micelles To Hydrogels

dc.creatorSantos Akkari
dc.creatorAlessandra Cristina; Ramos Campos
dc.creatorEstefania Vangelie; Keppler
dc.creatorArtur Franz; Fraceto
dc.creatorLeonardo Fernandes; de Paula
dc.creatorEneida; Tofoli
dc.creatorGiovana Radomille; de Araujo
dc.creatorDaniele Ribeiro
dc.date2016-FEB
dc.date2016-06-07T13:37:08Z
dc.date2016-06-07T13:37:08Z
dc.date.accessioned2018-03-29T01:52:19Z
dc.date.available2018-03-29T01:52:19Z
dc.identifier
dc.identifierBudesonide-hydroxypropyl-beta-cyclodextrin Inclusion Complex In Binary Poloxamer 407/403 System For Ulcerative Colitis Treatment: A Physico-chemical Study From Micelles To Hydrogels. Elsevier Science Bv, v. 138, p. 138-147 FEB-2016.
dc.identifier0927-7765
dc.identifierWOS:000368205100017
dc.identifier10.1016/j.colsurfb.2015.11.048
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0927776515303350
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/244426
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308124
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionBudesonide (BUD) is a glucocorticoid widely used for the treatment of ulcerative colitis. In this work, we propose the study of the system BUD-HP-beta-CD inclusion complex incorporated into PL 407 and PL407-PL403 thermoreversible hydrogels, considering physico-chemical and pharmaceutical aspects. Complexation between BUD and HP-beta-CD was confirmed by phase solubility studies (1:1 stoichiometry, Kc = 8662.8 M-1), DSC, FTIR and microscopy analyzes. BUD solubility in simulated upper and lower colon fluids was improved in a dependence of HP-beta-CD and PL 407 or PL407-PL403 association. Micellar hydrodynamic diameter studies showed the interaction between HP-beta-CD and PL blocks, as well as the reorganization of the micellar system in the presence of BUD and its inclusion complex. Micellization temperature (T-m) was not shifted, but sol-gel phase transition studies showed that in the presence of BUD, HP-beta-CD or BUD:HP-beta-CD complex, the association PL407-PL403 favored the gel formation close to the physiological temperature. Physico-chemical and in vitro release assays studies revealed no competitive displacement of BUD from the HP-beta-CD cavity evoked by PL407 or PL407-PL403 addition. These findings point out the BUD-HP-beta-CD in PL-based hydrogels as strategies for future investigations on development of new pharmaceutical formulations for the treatment of ulcerative colitis. (C) 2015 Elsevier B.V. All rights reserved.
dc.description138
dc.description
dc.description
dc.description138
dc.description147
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [FAPESP 2014/26200-9, 2014/14457-5]
dc.descriptionCNPq [CNPq 487619/2012-9, 309612/2013-6]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherELSEVIER SCIENCE BV
dc.publisher
dc.publisherAMSTERDAM
dc.relationCOLLOIDS AND SURFACES B-BIOINTERFACES
dc.rightsembargo
dc.sourceWOS
dc.subjectDrug-delivery
dc.subjectAqueous-solutions
dc.subjectTriblock Copolymers
dc.subjectHydrophobic Drugs
dc.subjectBlock-copolymers
dc.subjectMicellization
dc.subjectRelease
dc.subjectGelation
dc.subjectSpectroscopy
dc.subjectPolypseudorotaxanes
dc.titleBudesonide-hydroxypropyl-beta-cyclodextrin Inclusion Complex In Binary Poloxamer 407/403 System For Ulcerative Colitis Treatment: A Physico-chemical Study From Micelles To Hydrogels
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución