Arterial Tissue And Plasma Concentration Of Enzymatic-driven Oxysterols Are Associated With Severe Peripheral Atherosclerotic Disease And Systemic Infl Ammatory Activity

dc.creatorVirginio
dc.creatorV. W. M.; Nunes
dc.creatorV. S.; Moura
dc.creatorF. A.; Menezes
dc.creatorF. H.; Andreollo
dc.creatorN. A.; Rogerio
dc.creatorF.; Scherrer
dc.creatorD. Z.; Quintao
dc.creatorE. C. R.; Nakandakare
dc.creatorE.; Petrucci
dc.creatorO.; Nadruz-Junior
dc.creatorW.; de Faria
dc.creatorE. C.; Sposito
dc.creatorA. C.
dc.date2015-FEB
dc.date2016-06-07T13:37:07Z
dc.date2016-06-07T13:37:07Z
dc.date.accessioned2018-03-29T01:52:17Z
dc.date.available2018-03-29T01:52:17Z
dc.identifier
dc.identifierArterial Tissue And Plasma Concentration Of Enzymatic-driven Oxysterols Are Associated With Severe Peripheral Atherosclerotic Disease And Systemic Infl Ammatory Activity. Informa Healthcare, v. 49, p. 199-203 FEB-2015.
dc.identifier1071-5762
dc.identifierWOS:000349617800009
dc.identifier10.3109/10715762.2014.992894
dc.identifierhttp://www.tandfonline.com/doi/abs/10.3109/10715762.2014.992894?journalCode=ifra20
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/244420
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1308118
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionIntroduction. Cholesterol undergoes oxidation via both enzymatic stress-and free radical-mediated mechanisms, generating a wide range of oxysterols. In contrast to oxidative stress-driven metabolites, enzymatic stress-derived oxysterols are scarcely studied in their association with atherosclerotic disease in humans. Methods. 24S-hydroxycholesterol (24S-HC), 25-hydroxycholesterol (25-HC), and 27-hydroxycholesterol (27-HC) were assessed in plasma and arteries with atherosclerotic plaques from 10 patients (54 -84 years) with severe peripheral artery disease (PAD) as well as arteries free of atherosclerotic plaques from 13 individuals (45 - 78 years, controls). Results. Plasma 25-HC was higher in PAD individuals than in controls (6.3[2] vs. 3.9[1.9] ng/mgCol; p = 0.004). 24S-HC and 27-HC levels were, respectively, five-and 20-fold higher in the arterial tissue of PAD individuals than in those of the controls (p = 0.016 and p = 0.001). Plasma C-reactive protein correlated with plasma 24-HC (r = 0.51; p = 0.010), 25-HC (r = 0.75; p < 0.001), 27-HC (r = 0.48; p = 0.015), and with tissue 24S-HC (r = 0.4; p = 0.041) and 27-HC (r = 0.46; p = 0.023). Conclusion. Arterial intima accumulation of 27-HC and 24S-HC is associated with advanced atherosclerotic disease and systemic inflammatory activity in individuals with severe PAD.
dc.description49
dc.description2
dc.description
dc.description199
dc.description203
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCNPq [300313/2007-1]
dc.descriptionFAPESP [2006/60585-9]
dc.descriptionCNPq [471380/2008-13]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherINFORMA HEALTHCARE
dc.publisher
dc.publisherLONDON
dc.relationFREE RADICAL RESEARCH
dc.rightsembargo
dc.sourceWOS
dc.subjectCholesterol Oxidation
dc.subject24s-hydroxycholesterol
dc.subjectExpression
dc.subjectMacrophages
dc.subjectElimination
dc.subjectMetabolism
dc.subjectTransport
dc.subjectProducts
dc.subjectLesions
dc.subjectCells
dc.titleArterial Tissue And Plasma Concentration Of Enzymatic-driven Oxysterols Are Associated With Severe Peripheral Atherosclerotic Disease And Systemic Infl Ammatory Activity
dc.typeArtículos de revistas


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