Increased Arterial Stiffness In Resistant Hypertension Is Associated With Inflammatory Biomarkers

dc.creatorBarbaro
dc.creatorNatalia Ruggeri; Fontana
dc.creatorVanessa; Modolo
dc.creatorRodrigo; De Faria
dc.creatorAna Paula; Sabbatini
dc.creatorAndrea Rodrigues; Fonseca
dc.creatorFrancisco Helfenstein; Anhe
dc.creatorGabriel F.; Moreno
dc.creatorHeitor
dc.date2015-FEB
dc.date2016-06-07T13:36:17Z
dc.date2016-06-07T13:36:17Z
dc.date.accessioned2018-03-29T01:51:41Z
dc.date.available2018-03-29T01:51:41Z
dc.identifier
dc.identifierIncreased Arterial Stiffness In Resistant Hypertension Is Associated With Inflammatory Biomarkers. Informa Healthcare, v. 24, p. 7-13 FEB-2015.
dc.identifier0803-7051
dc.identifierWOS:000348187700002
dc.identifier10.3109/08037051.2014.940710
dc.identifierhttp://www.tandfonline.com/doi/abs/10.3109/08037051.2014.940710?journalCode=iblo20
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/244289
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1307987
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionBackground. Increased levels of inflammatory biomarkers such as interleukin-6 (IL-6), 10 (IL-10), 1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha) high-sensitivity C-reactive protein (hs-CRP) are associated with arterial stiffness in hypertension. Indeed, resistant hypertension (RHTN) leads to unfavorable prognosis attributed to poor blood pressure (BP) control and target organ damage. This study evaluated the potential impact of inflammatory biomarkers on arterial stiffness in RHTN. Methods. In this cross-sectional study, 32 RHTN, 20 mild hypertensive (HTN) and 20 normotensive (NT) patients were subjected to office BP and arterial stiffness measurements assessed by pulse wave velocity (PWV). Inflammatory biomarkers were measured in plasma samples. Results. PWV was increased in RHTN compared with HTN and NT (p < 0.05). TNF-alpha levels were significantly higher in RHTN and HTN than NT patients. No differences in IL-6 levels were observed. RHTN patients had a higher frequency of subjects with increased levels of IL-10 and IL-1 beta compared with HTN and NT patients. Finally, IL-1 beta was independently associated with PWV (p < 0.001; R-2 = 0.5; beta = 0.077). Conclusion. RHTN subjects have higher levels of infl ammatory cytokines (TNF-alpha, IL-1 beta and IL-10) as well as increased arterial stiffness, and detectable IL-1 beta levels are associated arterial stiffness. These findings suggest that inflammation plays a possible role in the pathophysiology of RHTN.
dc.description24
dc.description1
dc.description
dc.description7
dc.description13
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description
dc.description
dc.description
dc.languageen
dc.publisherINFORMA HEALTHCARE
dc.publisher
dc.publisherLONDON
dc.relationBLOOD PRESSURE
dc.rightsembargo
dc.sourceWOS
dc.subjectC-reactive Protein
dc.subjectNecrosis-factor-alpha
dc.subjectBlood-pressure
dc.subjectSystemic Inflammation
dc.subjectAortic Stiffness
dc.subjectVascular Stiffness
dc.subjectInterleukin-6
dc.subjectExpression
dc.subjectEndothelium
dc.subjectHypertrophy
dc.titleIncreased Arterial Stiffness In Resistant Hypertension Is Associated With Inflammatory Biomarkers
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución