Epigenetic Regulation Of Dna Repair Machinery In Helicobacter Pylori-induced Gastric Carcinogenesis

dc.creatorSantos
dc.creatorJuliana Carvalho; Ribeiro
dc.creatorMarcelo Lima
dc.date2015-AUG
dc.date2016-06-07T13:34:47Z
dc.date2016-06-07T13:34:47Z
dc.date.accessioned2018-03-29T01:50:23Z
dc.date.available2018-03-29T01:50:23Z
dc.identifier
dc.identifierEpigenetic Regulation Of Dna Repair Machinery In Helicobacter Pylori-induced Gastric Carcinogenesis. Baishideng Publishing Group Inc, v. 21, p. 9021-9037 AUG-2015.
dc.identifier1007-9327
dc.identifierWOS:000362233700004
dc.identifier10.3748/wjg.v21.i30.9021
dc.identifierhttp://www.wjgnet.com/1007-9327/full/v21/i30/9021.htm
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243983
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1307681
dc.descriptionAlthough thousands of DNA damaging events occur in each cell every day, efficient DNA repair pathways have evolved to counteract them. The DNA repair machinery plays a key role in maintaining genomic stability by avoiding the maintenance of mutations. The DNA repair enzymes continuously monitor the chromosomes to correct any damage that is caused by exogenous and endogenous mutagens. If DNA damage in proliferating cells is not repaired because of an inadequate expression of DNA repair genes, it might increase the risk of cancer. In addition to mutations, which can be either inherited or somatically acquired, epigenetic silencing of DNA repair genes has been associated with carcinogenesis. Gastric cancer represents the second highest cause of cancer mortality worldwide. The disease develops from the accumulation of several genetic and epigenetic changes during the lifetime. Among the risk factors, Helicobacter pylori (H. pylori) infection is considered the main driving factor to gastric cancer development. Thus, in this review, we summarize the current knowledge of the role of H. pylori infection on the epigenetic regulation of DNA repair machinery in gastric carcinogenesis.
dc.description21
dc.description30
dc.description
dc.description9021
dc.description9037
dc.description
dc.description
dc.description
dc.languageen
dc.publisherBAISHIDENG PUBLISHING GROUP INC
dc.publisher
dc.publisherPLEASANTON
dc.relationWORLD JOURNAL OF GASTROENTEROLOGY
dc.rightsfechado
dc.sourceWOS
dc.subjectBase Excision-repair
dc.subjectHistone H2ax Phosphorylation
dc.subjectSquamous-cell Carcinoma
dc.subjectDouble-strand Breaks
dc.subjectMicrosatellite Instability
dc.subjectMismatch Repair
dc.subjectEpithelial-cells
dc.subjectPromoter Hypermethylation
dc.subjectGene-expression
dc.subjectStomach-cancer
dc.titleEpigenetic Regulation Of Dna Repair Machinery In Helicobacter Pylori-induced Gastric Carcinogenesis
dc.typeArtículos de revistas


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