Assessment Of The Impact Of Potential Tetracycline Exposure On The Phenotype Of Aedes Aegypti Ox513a: Implications For Field Use

dc.creatorCurtis
dc.creatorZoe; Matzen
dc.creatorKelly; Oviedo
dc.creatorMarco Neira; Nimmo
dc.creatorDerric; Gray
dc.creatorPamela; Winskill
dc.creatorPeter; Locatelli
dc.creatorMarco A. F.; Jardim
dc.creatorWilson F.; Warner
dc.creatorSimon; Alphey
dc.creatorLuke; Beech
dc.creatorCamilla
dc.date2015-AUG
dc.date2016-06-07T13:34:14Z
dc.date2016-06-07T13:34:14Z
dc.date.accessioned2018-03-29T01:49:55Z
dc.date.available2018-03-29T01:49:55Z
dc.identifier
dc.identifierAssessment Of The Impact Of Potential Tetracycline Exposure On The Phenotype Of Aedes Aegypti Ox513a: Implications For Field Use. Public Library Science, v. 9, p. AUG-2015.
dc.identifier1935-2735
dc.identifierWOS:000360708200046
dc.identifier10.1371/journal.pntd.0003999
dc.identifierhttp://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003999
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243875
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1307573
dc.descriptionBackground Aedes aegypti is the primary vector of dengue fever, a viral disease which has an estimated incidence of 390 million infections annually. Conventional vector control methods have been unable to curb the transmission of the disease. We have previously reported a novel method of vector control using a tetracycline repressible self-limiting strain of Ae. aegypti OX513A which has achieved > 90% suppression of wild populations. Methodology/Principal Findings We investigated the impact of tetracycline and its analogues on the phenotype of OX513A from the perspective of possible routes and levels of environmental exposure. We determined the minimum concentration of tetracycline and its analogues that will allow an increased survivorship and found these to be greater than the maximum concentration of tetracyclines found in known Ae. aegypti breeding sites and their surrounding areas. Furthermore, we determined that OX513A parents fed tetracycline are unable to pre-load their progeny with sufficient antidote to increase their survivorship. Finally, we studied the changes in concentration of tetracycline in the mass production rearing water of OX513A and the developing insect. Conclusion/Significance Together, these studies demonstrate that potential routes of exposure of OX513A individuals to tetracycline and its analogues in the environment are not expected to increase the survivorship of OX513A.
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dc.descriptionOxitec's core investment
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dc.languageen
dc.publisherPUBLIC LIBRARY SCIENCE
dc.publisher
dc.publisherSAN FRANCISCO
dc.relationPLOS NEGLECTED TROPICAL DISEASES
dc.rightsaberto
dc.sourceWOS
dc.subjectSolid-phase Extraction
dc.subjectTandem Mass-spectrometry
dc.subjectWaste-water
dc.subjectSeptic Tanks
dc.subjectHong-kong
dc.subjectAntibiotics
dc.subjectDengue
dc.subjectSulfonamide
dc.subjectPh
dc.subjectOxytetracycline
dc.titleAssessment Of The Impact Of Potential Tetracycline Exposure On The Phenotype Of Aedes Aegypti Ox513a: Implications For Field Use
dc.typeArtículos de revistas


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