Ghost Cells In Pilomatrixoma, Craniopharyngioma, And Calcifying Cystic Odontogenic Tumor: Histological, Immunohistochemical, And Ultrastructural Study

dc.creatorRumayor
dc.creatorAlicia; Carlos
dc.creatorRoman; Molina Kirsch
dc.creatorHernan; Benevenuto de Andrade
dc.creatorBruno A.; Romanach
dc.creatorMario J.; de Almeida
dc.creatorOslei Paes
dc.date2015-APR
dc.date2016-06-07T13:33:33Z
dc.date2016-06-07T13:33:33Z
dc.date.accessioned2018-03-29T01:49:18Z
dc.date.available2018-03-29T01:49:18Z
dc.identifier
dc.identifierGhost Cells In Pilomatrixoma, Craniopharyngioma, And Calcifying Cystic Odontogenic Tumor: Histological, Immunohistochemical, And Ultrastructural Study. Wiley-blackwell, v. 44, p. 284-290 APR-2015.
dc.identifier0904-2512
dc.identifierWOS:000352623300008
dc.identifier10.1111/jop.12234
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/jop.12234/abstract
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243729
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1307427
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionBackgroundPilomatrixoma, craniopharyngioma, and calcifying cystic odontogenic tumor are the main entities presenting ghost cells as an important histological feature, in spite their quite different clinical presentation; it seems that they share a common pathway in the formation of these cells. The aim of this study is to examine and compare the characteristics of ghost and other cells that form these lesions. MethodsForty-three cases including 21 pilomatrixomas, 14 craniopharyngiomas, and eight calcifying cystic odontogenic tumors were evaluated by immunohistochemistry for cytokeratins, CD138, -catenin, D2-40, Glut-1, FAS, CD10 and also by scanning electron microscopy. ResultsThe CKs, CD138, -catenin, Glut-1, FAS, and CD10 were more often expressed by transitional cells of craniopharyngioma and calcifying cystic odontogenic tumor, compared with pilomatrixoma. Basaloid cells of pilomatrixoma showed strong positivity for CD138 and CD10. Differences on expression pattern were identified in transitional and basal cells, as ghost cells were negative for most antibodies used, except by low expression for cytokeratins. By scanning electron microscopy, the morphology of ghost cells were similar in their fibrillar cytoplasm, but their pattern varied from sheets in pilomatrixoma to small clusters in craniopharyngioma and calcifying cystic odontogenic tumor. ConclusionsMechanisms involved in formation of ghost cells are unknown, but probably they follow different pathways as protein expression in the basal/transitional cells was not uniform in the three tumors studied.
dc.description44
dc.description4
dc.description
dc.description284
dc.description290
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description
dc.description
dc.description
dc.languageen
dc.publisherWILEY-BLACKWELL
dc.publisher
dc.publisherHOBOKEN
dc.relationJOURNAL OF ORAL PATHOLOGY & MEDICINE
dc.rightsfechado
dc.sourceWOS
dc.subjectBeta-catenin Gene
dc.subjectExpression
dc.subjectKeratinization
dc.subjectEpithelioma
dc.subjectCarcinoma
dc.subjectMutations
dc.subjectPathway
dc.subjectSkin
dc.titleGhost Cells In Pilomatrixoma, Craniopharyngioma, And Calcifying Cystic Odontogenic Tumor: Histological, Immunohistochemical, And Ultrastructural Study
dc.typeArtículos de revistas


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