Neurotransmitters And Neuropeptides: New Players In The Control Of Islet Of Langerhans' Cell Mass And Function

dc.creatorDi Cairano
dc.creatorEliana S.; Moretti
dc.creatorStefania; Marciani
dc.creatorPaola; Sacchi
dc.creatorVellea Franca; Castagna
dc.creatorMichela; Davalli
dc.creatorAlberto; Folli
dc.creatorFranco; Perego
dc.creatorCarla
dc.date2016-APR
dc.date2016-06-07T13:33:16Z
dc.date2016-06-07T13:33:16Z
dc.date.accessioned2018-03-29T01:49:02Z
dc.date.available2018-03-29T01:49:02Z
dc.identifier
dc.identifierNeurotransmitters And Neuropeptides: New Players In The Control Of Islet Of Langerhans' Cell Mass And Function. Wiley-blackwell, v. 231, p. 756-767 APR-2016.
dc.identifier0021-9541
dc.identifierWOS:000368274100002
dc.identifier10.1002/jcp.25176
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1002/jcp.25176/abstract
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243663
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1307361
dc.descriptionIslets of Langerhans control whole body glucose homeostasis, as they respond, releasing hormones, to changes in nutrient concentrations in the blood stream. The regulation of hormone secretion has been the focus of attention for a long time because it is related to many metabolic disorders, including diabetes mellitus. Endocrine cells of the islet use a sophisticate system of endocrine, paracrine and autocrine signals to synchronize their activities. These signals provide a fast and accurate control not only for hormone release but also for cell differentiation and survival, key aspects in islet physiology and pathology. Among the different categories of paracrine/autocrine signals, this review highlights the role of neurotransmitters and neuropeptides. In a manner similar to neurons, endocrine cells synthesize, accumulate, release neurotransmitters in the islet milieu, and possess receptors able to decode these signals. In this review, we provide a comprehensive description of neurotransmitter/neuropetide signaling pathways present within the islet. Then, we focus on evidence supporting the concept that neurotransmitters/neuropeptides and their receptors are interesting new targets to preserve beta-cell function and mass. A greater understanding of how this network of signals works in physiological and pathological conditions would advance our knowledge of islet biology and physiology and uncover potentially new areas of pharmacological intervention. (C) 2015 Wiley Periodicals, Inc.
dc.description231
dc.description4
dc.description
dc.description756
dc.description767
dc.descriptionUniversita degli Studi di Milano
dc.description
dc.description
dc.description
dc.languageen
dc.publisherWILEY-BLACKWELL
dc.publisher
dc.publisherHOBOKEN
dc.relationJOURNAL OF CELLULAR PHYSIOLOGY
dc.rightsfechado
dc.sourceWOS
dc.subjectPancreatic Beta-cells
dc.subjectCyclase-activating Polypeptide
dc.subjectGamma-aminobutyric-acid
dc.subjectSynaptic-like Microvesicles
dc.subjectGlucagon-like Peptide-1
dc.subjectVasoactive Intestinal Polypeptide
dc.subjectStimulated Insulin-secretion
dc.subjectPositive Autocrine Signal
dc.subjectAlpha-cells
dc.subjectGlucose-homeostasis
dc.titleNeurotransmitters And Neuropeptides: New Players In The Control Of Islet Of Langerhans' Cell Mass And Function
dc.typeArtículos de revistas
dc.typeResumo


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