In Vivo Nanotoxicology Of Hybrid Systems Based On Copolymer/silica/anticancer Drug

dc.creatorSilveira
dc.creatorC. P.; Paula
dc.creatorA. J.; Apolinario
dc.creatorL. M.; Favaro
dc.creatorW. J.; Duran
dc.creatorN.
dc.date2015
dc.date2016-06-07T13:33:08Z
dc.date2016-06-07T13:33:08Z
dc.date.accessioned2018-03-29T01:48:53Z
dc.date.available2018-03-29T01:48:53Z
dc.identifier
dc.identifierIn Vivo Nanotoxicology Of Hybrid Systems Based On Copolymer/silica/anticancer Drug. Iop Publishing Ltd, v. 617, p. 2015.
dc.identifier1742-6588
dc.identifierWOS:000358033300024
dc.identifier10.1088/1742-6596/617/1/012024
dc.identifierhttp://iopscience.iop.org/article/10.1088/1742-6596/617/1/012024/meta
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243626
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1307324
dc.descriptionOne of the major problems in cancer therapies is the high occurrence of side effects intrinsic of anticancer drugs. Doxorrubicin is a conventional anticancer molecule used to treat a wide range of cancer, such as breast, ovarian and prostate. However, its use is associated with a number of side effects like multidrug resistance and cardiotoxicity. The association with nanomaterials has been considered in the past decade to overcome the high toxicity of these drugs. In this context, mesoporous silica nanoparticles are great candidates to be used as carriers once they are very biocompatible. Taking into account the combination of nanoparticles and doxorrubicin, we treated rats with chemically induced prostate cancer with systems based on mesoporous silica nanoparticles and a thermoreversible block copolymer (Pluronic F-127) containing doxorrubicin. Preliminary results show a possible improvement in tumor conditions proportional to the concentration of the nanoparticles, opening a perspective to use mesoporous silica nanoparticles as carrier for doxorrubicin in prostate cancer treatment.
dc.description617
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dc.languageen
dc.publisherIOP PUBLISHING LTD
dc.publisher
dc.publisherBRISTOL
dc.relation4TH INTERNATIONAL CONFERENCE ON SAFE PRODUCTION AND USE OF NANOMATERIALS (NANOSAFE2014)
dc.rightsaberto
dc.sourceWOS
dc.subjectMesoporous Silica Nanoparticles
dc.subjectModulation
dc.titleIn Vivo Nanotoxicology Of Hybrid Systems Based On Copolymer/silica/anticancer Drug
dc.typeActas de congresos


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